STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
drsh-1Ribonuclease 3; Executes the initial step of microRNA (miRNA) processing in the nucleus, that is the cleavage of pri-miRNA to release pre-miRNA. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in fertility. Required for the function or synthesis of the let-7 miRNA. Belongs to the ribonuclease III family. (1086 aa)    
Predicted Functional Partners:
pash-1
PArtner of DroSHa (DRSH-1 interactor).
   
 0.999
rde-4
RNA interference promoting factor.
   
 0.973
xpo-1
Importin N-terminal domain-containing protein.
   
 
 0.898
mrps-9
Probable 40S ribosomal protein S9, mitochondrial; Belongs to the universal ribosomal protein uS9 family.
   
 
 0.887
mrpl-19
Probable 39S ribosomal protein L19, mitochondrial.
  
 
 0.884
mrps-6
Mitochondrial Ribosomal Protein, Small.
   
 
 0.868
lin-28
Protein lin-28; Heterochronic protein which controls the choice of stage specific cell fates. Regulates the timing of the second larval stage events (L2 events) in the hypodermis. May negatively regulate the larval to adult transition via the suppression of the microRNA (miRNA) let-7 during L3. Plays a role in the control of seam cell number and vulval development. Belongs to the lin-28 family.
  
 
 0.858
mrpl-17
Mitochondrial Ribosomal Protein, Large.
   
 
 0.858
Y55F3BL.4
SRR1 domain-containing protein.
   
 
 0.854
mrpl-34
L51_S25_CI-B8 domain-containing protein.
   
 
 0.848
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.