STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aat-1Amino Acid Transporter. (493 aa)    
Predicted Functional Partners:
atgp-2
Aamy domain-containing protein.
   
 0.989
atgp-1
Aamy domain-containing protein.
   
 
 0.950
vglu-3
Potential vesicular glutamate transporter vglu-3.
      
 0.759
atg-2
Autophagy-related protein 2; Component of the epg-6/atg-2 complex, which is involved in the generation of autophagosomes from omegasomes and in the distribution of atg-9 and atg-13 during the autophagy-mediated degradation of protein aggregates. Involved in autophagy-mediated degradation of ribosomal RNA and ribosomal proteins in lysosomes, which is essential for maintaining nucleotide homeostasis.
      
 0.753
aat-3
Amino Acid Transporter.
  
 
0.730
swip-10
Lactamase_B domain-containing protein.
   
  
 0.720
nrfl-1
Na(+)/H(+) exchange regulatory cofactor-like protein nrfl-1; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression (By similarity). Anchors the amino acid transporter protein aat-6 to the apical cell membrane of intestinal cells, particularly in older animals, in order to maintain amino acid homeostasis. May play a role in promoting fertility.
   
  
 0.719
ttc-36
Tetratricopeptide repeat protein 36; Belongs to the TTC36 family.
      
 0.692
pssy-1
PhosphatidylSerine SYnthase.
      
 0.660
nmr-2
NMDA-type ionotropic glutamate receptor NMR-2.
      
 0.620
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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