Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cpx-1 | lin-10 | Y73E7A.4.1 | C09H6.2a.1 | Putative complexin-1; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family. | Protein lin-10; Required specifically for the determination of 3 vulval precursor cell fates P5.p, P6.p and P7.p during late second and early third larval stages; required for basolateral localization of receptor tyrosine kinase let-23. Could have a general but redundant role in development, functioning in diverse cell lineages to control cell fates. Regulates the trafficking of the glutamate receptor glr-1 in the ventral nerve cord. | 0.508 |
| cpx-1 | rab-3 | Y73E7A.4.1 | C18A3.6a.1 | Putative complexin-1; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family. | Ras-related protein Rab-3; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). Plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by controlling dense-core vesicle trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Belongs to the small GTPase superfamily. Rab family. | 0.717 |
| cpx-1 | ric-4 | Y73E7A.4.1 | Y22F5A.3b.1 | Putative complexin-1; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family. | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | 0.839 |
| cpx-1 | snb-1 | Y73E7A.4.1 | T10H9.4.1 | Putative complexin-1; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family. | Synaptobrevin-1; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Acts in neuronal exocytosis of synaptic transmission. Likely to have a role in cholinergic transmisson. Required for viability, coordinated movement and M3 pharynx motor neuron function. | 0.721 |
| cpx-1 | snt-1 | Y73E7A.4.1 | F31E8.2b.1 | Putative complexin-1; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family. | Synaptotagmin-1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (By similarity). Involved in necrotic cell death. | 0.789 |
| cpx-1 | snt-3 | Y73E7A.4.1 | Y75B7AL.3.1 | Putative complexin-1; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family. | SyNapTotagmin. | 0.636 |
| cpx-1 | unc-10 | Y73E7A.4.1 | T10A3.1a.1 | Putative complexin-1; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family. | Rab-3-interacting molecule unc-10; Regulates the efficiency of a post-docking step of the release pathway. Acts after vesicle docking likely via regulating priming. May regulate the conformational changes in syntaxin. Binding of vesicles via rab-3[GTP] to Rim may signal the presence of a docked synaptic vesicle. Rim may then signal to unc-13 to change the conformation of syntaxin from the closed to the open state. Syntaxin could then engage synaptobrevin on the docked vesicle to form SNARE complexes and to prime the vesicle for release. Not required for the development or the structura [...] | 0.898 |
| cpx-1 | unc-13 | Y73E7A.4.1 | ZK524.2d.1 | Putative complexin-1; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family. | Phorbol ester/diacylglycerol-binding protein unc-13; May form part of a signal transduction pathway, transducing the signal from diacylglycerol to effector functions. One such function could be the release of neurotransmitter from neurons. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt. | 0.800 |
| cpx-1 | unc-18 | Y73E7A.4.1 | F27D9.1a.1 | Putative complexin-1; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family. | Putative acetylcholine regulator unc-18; May participate in the axonal transport system and influences the acetylcholine flow in motor neurons. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt ; Belongs to the STXBP/unc-18/SEC1 family. | 0.873 |
| cpx-1 | unc-64 | Y73E7A.4.1 | F56A8.7a.2 | Putative complexin-1; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family. | Syntaxin-1A homolog; Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation. Essential for embryonic viability and development. Has a role in dauer formation and adult life span. Required for locomotion. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the qui [...] | 0.867 |
| lin-10 | cpx-1 | C09H6.2a.1 | Y73E7A.4.1 | Protein lin-10; Required specifically for the determination of 3 vulval precursor cell fates P5.p, P6.p and P7.p during late second and early third larval stages; required for basolateral localization of receptor tyrosine kinase let-23. Could have a general but redundant role in development, functioning in diverse cell lineages to control cell fates. Regulates the trafficking of the glutamate receptor glr-1 in the ventral nerve cord. | Putative complexin-1; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family. | 0.508 |
| lin-10 | rab-3 | C09H6.2a.1 | C18A3.6a.1 | Protein lin-10; Required specifically for the determination of 3 vulval precursor cell fates P5.p, P6.p and P7.p during late second and early third larval stages; required for basolateral localization of receptor tyrosine kinase let-23. Could have a general but redundant role in development, functioning in diverse cell lineages to control cell fates. Regulates the trafficking of the glutamate receptor glr-1 in the ventral nerve cord. | Ras-related protein Rab-3; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). Plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by controlling dense-core vesicle trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Belongs to the small GTPase superfamily. Rab family. | 0.524 |
| lin-10 | ric-4 | C09H6.2a.1 | Y22F5A.3b.1 | Protein lin-10; Required specifically for the determination of 3 vulval precursor cell fates P5.p, P6.p and P7.p during late second and early third larval stages; required for basolateral localization of receptor tyrosine kinase let-23. Could have a general but redundant role in development, functioning in diverse cell lineages to control cell fates. Regulates the trafficking of the glutamate receptor glr-1 in the ventral nerve cord. | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | 0.583 |
| lin-10 | snb-1 | C09H6.2a.1 | T10H9.4.1 | Protein lin-10; Required specifically for the determination of 3 vulval precursor cell fates P5.p, P6.p and P7.p during late second and early third larval stages; required for basolateral localization of receptor tyrosine kinase let-23. Could have a general but redundant role in development, functioning in diverse cell lineages to control cell fates. Regulates the trafficking of the glutamate receptor glr-1 in the ventral nerve cord. | Synaptobrevin-1; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Acts in neuronal exocytosis of synaptic transmission. Likely to have a role in cholinergic transmisson. Required for viability, coordinated movement and M3 pharynx motor neuron function. | 0.719 |
| lin-10 | snt-1 | C09H6.2a.1 | F31E8.2b.1 | Protein lin-10; Required specifically for the determination of 3 vulval precursor cell fates P5.p, P6.p and P7.p during late second and early third larval stages; required for basolateral localization of receptor tyrosine kinase let-23. Could have a general but redundant role in development, functioning in diverse cell lineages to control cell fates. Regulates the trafficking of the glutamate receptor glr-1 in the ventral nerve cord. | Synaptotagmin-1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (By similarity). Involved in necrotic cell death. | 0.520 |
| lin-10 | snt-3 | C09H6.2a.1 | Y75B7AL.3.1 | Protein lin-10; Required specifically for the determination of 3 vulval precursor cell fates P5.p, P6.p and P7.p during late second and early third larval stages; required for basolateral localization of receptor tyrosine kinase let-23. Could have a general but redundant role in development, functioning in diverse cell lineages to control cell fates. Regulates the trafficking of the glutamate receptor glr-1 in the ventral nerve cord. | SyNapTotagmin. | 0.502 |
| lin-10 | unc-10 | C09H6.2a.1 | T10A3.1a.1 | Protein lin-10; Required specifically for the determination of 3 vulval precursor cell fates P5.p, P6.p and P7.p during late second and early third larval stages; required for basolateral localization of receptor tyrosine kinase let-23. Could have a general but redundant role in development, functioning in diverse cell lineages to control cell fates. Regulates the trafficking of the glutamate receptor glr-1 in the ventral nerve cord. | Rab-3-interacting molecule unc-10; Regulates the efficiency of a post-docking step of the release pathway. Acts after vesicle docking likely via regulating priming. May regulate the conformational changes in syntaxin. Binding of vesicles via rab-3[GTP] to Rim may signal the presence of a docked synaptic vesicle. Rim may then signal to unc-13 to change the conformation of syntaxin from the closed to the open state. Syntaxin could then engage synaptobrevin on the docked vesicle to form SNARE complexes and to prime the vesicle for release. Not required for the development or the structura [...] | 0.689 |
| lin-10 | unc-13 | C09H6.2a.1 | ZK524.2d.1 | Protein lin-10; Required specifically for the determination of 3 vulval precursor cell fates P5.p, P6.p and P7.p during late second and early third larval stages; required for basolateral localization of receptor tyrosine kinase let-23. Could have a general but redundant role in development, functioning in diverse cell lineages to control cell fates. Regulates the trafficking of the glutamate receptor glr-1 in the ventral nerve cord. | Phorbol ester/diacylglycerol-binding protein unc-13; May form part of a signal transduction pathway, transducing the signal from diacylglycerol to effector functions. One such function could be the release of neurotransmitter from neurons. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt. | 0.528 |
| lin-10 | unc-18 | C09H6.2a.1 | F27D9.1a.1 | Protein lin-10; Required specifically for the determination of 3 vulval precursor cell fates P5.p, P6.p and P7.p during late second and early third larval stages; required for basolateral localization of receptor tyrosine kinase let-23. Could have a general but redundant role in development, functioning in diverse cell lineages to control cell fates. Regulates the trafficking of the glutamate receptor glr-1 in the ventral nerve cord. | Putative acetylcholine regulator unc-18; May participate in the axonal transport system and influences the acetylcholine flow in motor neurons. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt ; Belongs to the STXBP/unc-18/SEC1 family. | 0.895 |
| lin-10 | unc-64 | C09H6.2a.1 | F56A8.7a.2 | Protein lin-10; Required specifically for the determination of 3 vulval precursor cell fates P5.p, P6.p and P7.p during late second and early third larval stages; required for basolateral localization of receptor tyrosine kinase let-23. Could have a general but redundant role in development, functioning in diverse cell lineages to control cell fates. Regulates the trafficking of the glutamate receptor glr-1 in the ventral nerve cord. | Syntaxin-1A homolog; Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation. Essential for embryonic viability and development. Has a role in dauer formation and adult life span. Required for locomotion. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the qui [...] | 0.867 |
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