STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gex-3Membrane-associated protein gex-3; Rac effector required for tissue morphogenesis, cell migrations and egg laying. May play a role in egg laying and in yolk protein clatherin-mediated endocytosis by oocytes during oogenesis. (1141 aa)    
Predicted Functional Partners:
gex-2
Cytoplasmic FMR1-interacting protein homolog; Required for initial steps of body morphogenesis. May play a role in egg laying and yolk protein clatherin-mediated endocytosis by oocytes during oogenesis. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord.
   
 0.999
wve-1
WH2 domain-containing protein.
   
 0.999
abi-1
SH3 domain-containing protein.
   
 0.998
Y57G11C.1147
Uncharacterized protein.
    
 0.990
ced-10
Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...]
   
 0.880
wsp-1
WASP (Actin cytoskeleton modulator) homolog.
   
 
 0.869
arx-2
Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).
   
 0.860
nap-1
Nucleosome Assembly Protein; Belongs to the nucleosome assembly protein (NAP) family.
      
 0.846
nck-1
NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family.
    
 0.763
rac-2
Ras-related protein rac-2; During gonad morphogenesis, plays a role in distal tip cell (DTC)-mediated guidance of gonad elongation.
   
 0.760
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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