STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cpn-3Calponin-homology (CH) domain-containing protein. (142 aa)    
Predicted Functional Partners:
act-5
ACTin.
   
 
 0.986
unc-87
Protein unc-87; Thin filament-associated protein that is implicated in actin bundling and actin filament dynamics. Exhibits F-actin cross-linking activity. Required for the maintenance of sarcomeric actin organization in striated muscles. Competes with unc-60 isoform b for actin binding and protects actin filaments from depolymerization by unc-60, thereby contributing to actin filament stability. Cooperates with myosin to form actomyosin bundles and inhibits actomyosin ATPase activity and actomyosin motility. Might protect the myofilaments from mechanical stress.
   
 
 0.930
cal-1
Calmodulin-like protein; This protein resembles calmodulin in sequence but possibly resembles troponin C in function.
   
 
 0.866
cmd-1
Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
   
 
 0.861
atn-1
AcTiniN.
   
  
 0.855
cal-2
CALmodulin related genes.
   
 
 0.851
cal-3
CALmodulin related genes.
   
 
 0.851
fln-2
FiLamiN (Actin binding protein) homolog.
   
  
 0.850
cal-4
CALmodulin related genes.
   
 
 0.850
K03A1.4
EF-hand domain-containing protein.
   
 
 0.848
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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