STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aars-2Alanine--tRNA ligase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (968 aa)    
Predicted Functional Partners:
ears-2
tRNA-synt_1c domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 
 0.974
lars-2
Anticodon_1 domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 
 0.957
dars-2
AA_TRNA_LIGASE_II domain-containing protein.
 
  
 0.955
fars-2
Mitochondrial phenylalanyl-tRNA synthetase.
  
  
 0.954
gars-1
Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. Belongs to the class-II aminoacyl-tRNA synthetase family.
  
 
 0.948
yars-2
Tyrosine--tRNA ligase.
  
 
 0.945
qars-1
Probable glutamine--tRNA ligase.
  
 
 0.940
pars-2
AA_TRNA_LIGASE_II domain-containing protein.
   
  
 0.925
rars-2
DALR_1 domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 
 0.923
nars-2
AA_TRNA_LIGASE_II domain-containing protein.
  
 
 0.921
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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