STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bath-45BTB and MATH domain-containing protein 45. (468 aa)    
Predicted Functional Partners:
Y75B8A.19
Uncharacterized protein.
   
 
 0.895
hrde-1
Uncharacterized protein C16C10.3.
    
 
 0.769
zfp-1
Zinc finger protein zfp-1; Recruits the histone methyltransferase dot-1.1 to chromatin to methylate 'Lys-79' of histone H3 and activate transcription. Recognizes and binds histone H3 methylated at 'Lys- 4' (H3K4me) at the promoters of target genes. During stress, the zfp-1-dot-1.1 complex also plays a role in the deubiquitination of histone H2B sites, which negatively modulates the RNA polymerase II-induced transcription of highly expressed genes. In response to stress, binds to the pdk-1 promoter to negatively regulate pdk-1 expression, which negatively modulates daf-16/FOXO-mediated [...]
      
 0.698
tofu-1
Twenty One u-rna (21U-RNA) biogenesis Fouled Up.
      
 0.660
prde-1
piRNA biogenesis factor prde-1; Nuclear factor required for the production of piwi- interacting RNA (piRNA) precursors. Specifically required for piRNAs produced from loci associated with the Ruby motif. Promotes binding of the transcription factor snpc-4 at piRNA genomic clusters. Required for normal fertility.
    
 
 0.630
glb-14
GLOBIN domain-containing protein; Belongs to the globin family.
   
 
 0.629
tofu-2
B30.2/SPRY domain-containing protein.
    
 
 0.560
tofu-4
Twenty One u-rna (21U-RNA) biogenesis Fouled Up.
      
 0.549
Y80D3A.8
Uncharacterized protein.
   
 
 0.523
golg-2
GOLGi associated coiled-coil protein homolog.
   
 
 0.503
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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