STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
grld-1Glutamate Receptor Level Decreased. (520 aa)    
Predicted Functional Partners:
Y38C1AA.1
PlsC domain-containing protein.
   
  
 0.913
T16G12.6
Xpo1 domain-containing protein.
   
  
 0.819
mbl-1
Muscleblind-like protein; Binds to RNA with repeat sequences 5'-CUG-3' and 5'-CCUG-3'.
      
 0.690
glr-1
Glutamate receptor 1; Non-NMDA (N-methyl-D-aspartate) ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of glutamate are mediated by a variety of receptors that are named according to their selective agonists. May contribute to a sensory discrimination between mechanical and chemical stimuli. Plays a role in controlling movement in response to environmental cues such as food availability and mechanosensory stimulation such as the nose touch response. In AIB interneurons, promotes om [...]
      
 0.660
thoc-2
THO Complex (Transcription factor/nuclear export) subunit.
   
 
 0.601
mett-10
U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that mediates N6-methylation of adenine of U6 small nuclear RNA (U6 snRNA) (By similarity). Involved in mRNA splicing (By similarity). Required for gamete production, inhibiting germ cell proliferative fate and ensuring germ cell meiotic development. Also promotes progression of the mitotic cell cycle in those germ cells that continue to proliferate. Plays a role in the development of the vulva, somatic gonad and embryo. Belongs to the methyltransferase superfamily. METTL16/RlmF family.
   
  
 0.555
glr-2
Glutamate receptor 2; L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of glutamate are mediated by a variety of receptors that are named according to their selective agonists. Required for response to mechanical and osmotic stimuli; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
      
 0.534
lag-1
Lin-12 And Glp-1 phenotype.
   
 
 0.532
rig-1
NeuRonal IGCAM.
      
 0.531
nxf-1
Nuclear RNA export factor 1; Involved in RNA export from the nucleus to the cytoplasm; Belongs to the NXF family.
    
 
 0.513
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.