STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
twk-12TWiK family of potassium channels protein 12. (684 aa)    
Predicted Functional Partners:
nlp-39
Neuropeptide-Like Protein.
      
 0.896
egas-1
EGF plus ASC domain ion channel; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
   
  
 0.852
asic-2
Degenerin-like protein asic-2.
   
  
 0.811
srt-62
Serpentine Receptor, class T.
      
 0.760
srsx-24
G_PROTEIN_RECEP_F1_2 domain-containing protein.
      
 0.758
srsx-22
G_PROTEIN_RECEP_F1_2 domain-containing protein.
      
 0.758
npr-23
G_PROTEIN_RECEP_F1_2 domain-containing protein.
   
  
 0.698
sup-9
Two pore potassium channel protein sup-9; Potassium channel involved in coordination of muscle contraction. Activity is regulated by sup-18 ; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
   
 
0.598
twk-14
TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
   
 
0.591
nlp-36
Neuropeptide-like peptide 36.
      
 0.584
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (20%) [HD]