STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
stl-1PHB domain-containing protein. (324 aa)    
Predicted Functional Partners:
phb-1
Mitochondrial prohibitin complex protein 1; PHB proteins are essential during embryonic development and are required for somatic and germline differentiation in the larval gonad. A deficiency in PHB proteins results in altered mitochondrial biogenesis in body wall muscle cells.
   
 
 0.861
phb-2
Mitochondrial prohibitin complex protein 2; PHB proteins are essential during embryonic development and are required for somatic and germline differentiation in the larval gonad. A deficiency in PHB proteins results in altered mitochondrial biogenesis in body wall muscle cells.
   
 
 0.841
mans-1
alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.
   
  
 0.816
B0041.5
Uncharacterized protein.
   
  
 0.812
slc-25A42
SLC (SoLute Carrier) homolog; Belongs to the mitochondrial carrier (TC 2.A.29) family.
   
  
 0.810
oac-9
NRF domain-containing protein.
      
 0.809
mrps-7
28S ribosomal protein S7, mitochondrial; Belongs to the universal ribosomal protein uS7 family.
   
 
 0.694
csn-5
COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of [...]
   
 
 0.677
erl-1
Erlin.
   
 
 0.673
mrpl-2
Ribosomal_L2_C domain-containing protein.
   
   0.606
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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