STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
stn-1Syntrophin-1; Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (DGC). May also act by slowing calcium channel activity via a direct or indirect mechanism potentially involving other second messengers. Plays an early role in the formation of the neuromuscular junction and is necessary for muscle maintenance. (440 aa)    
Predicted Functional Partners:
dyb-1
Dystrobrevin-1; Plays a role in cholinergic transmission and as a functional partner of dystrophin (dys-1), necessary for muscle maintenance.
   
 0.996
dys-1
Dystrophin-1; Plays a role in cholinergic transmission and as a functional partner of dystrobrevin (dyb-1), necessary for muscle maintenance. Required for neuronal positioning.
   
 0.990
islo-1
Interactor with SLO-1.
   
 
 0.958
sgca-1
CADG domain-containing protein.
   
 0.930
dyc-1
Dystrophin-like protein 1; Together with dys-1 and hlh-1, participates in a common muscular function.
   
 0.906
sgn-1
SarcoGlycaN.
   
 
 0.898
sgcb-1
SarcoGlyCan Beta homolog.
   
 
 0.872
ctn-1
Alpha-CaTuliN (Catenin/vinculin related).
   
 
 0.852
stn-2
PDZ domain-containing protein.
   
0.814
dgn-1
Peptidase S72 domain-containing protein.
    
 0.761
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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