STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
zipt-1Zrt (ZRT), Irt-(IRT-) like Protein Transporter. (318 aa)    
Predicted Functional Partners:
zipt-7.1
Zinc transporter zipt-7.1; Zinc transporter which regulates intracellular zinc levels. Required for spermatogenesis in both hermaphrodites and males where it resides in an inactive form in immature sperm, spermatids, but is likely activated in response to reduced spe-4 and spe-6 function. Upon activation, mediates the release of zinc from internal stores in spermatids into the cytoplasm. The resulting increase in cytoplasmic zinc levels promotes spermatid activation and subsequent differentiation into mature motile sperm that are capable of fertilization.
   
 
 0.902
Y105E8A.3
SLC (SoLute Carrier) homolog.
   
 
 0.878
zipt-13
Zrt (ZRT), Irt-(IRT-) like Protein Transporter.
   
 
 0.857
zipt-2.3
Zrt (ZRT), Irt-(IRT-) like Protein Transporter.
  
  
0.610
mtx-1
Metaxin-1 homolog; Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity); Belongs to the metaxin family.
   
 
 0.599
zipt-7.2
Zinc transporter zipt-7.2; Zinc transporter.
   
 
 0.598
F31C3.3
Fmp27_GFWDK domain-containing protein.
 
      0.575
gop-3
SAM50-like protein gop-3; May play a role in the maintenance of the structure of mitochondrial cristae; Belongs to the SAM50/omp85 family.
   
 
 0.573
zip-7
BZIP domain-containing protein.
      
 0.531
zipt-2.4
Zrt (ZRT), Irt-(IRT-) like Protein Transporter.
  
 
 
0.525
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (6%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.