STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
daf-6SSD domain-containing protein. (913 aa)    
Predicted Functional Partners:
che-14
SSD domain-containing protein.
   
  
 0.886
dyf-7
Protein dyf-7; Required for permeability of amphid and phasmid neurons to external dyes, chemotaxis to ammonium chloride, avoidance of high osmotic stimuli, male mating and dauer formation. Along with dex-1, enables neurite growth and maintenance by anchoring amphid dendritic tips during neuron cell body migration in embryonic and larval development.
   
  
 0.700
T02B11.3
Uncharacterized protein.
      
 0.695
igdb-2
Ig-like and fibronectin type-III domain-containing protein 2.
      
 0.694
lit-1
Serine/threonine kinase NLK; Has a role in the Wnt signaling pathway controlling the asymmetry of cell divisions during embryogenesis. Operates in the AB and EMS cell lineages influencing cell specification. Required for body wall muscle development, endoderm development, pop-1 asymmetry and T- cell division asymmetry. Lit-1/wrm-1 complex regulates pop-1 localization and is required for pop-1/par-5 interaction. Plays a role in male tail tip morphogenesis.
      
 0.692
daf-10
Intraflagellar transport protein 122 homolog; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs). Plays a role in chemotaxis and sensory perception. Required for entry into and exit from the dauer larval stage and this may be mediated by daf-12, daf-16 and daf-41. Controls the behavioral response, namely the avoidance response, and pathogen-responsive gene expression in the response to pathogenic bacteria such as E.coli and P. aeruginosa.
   
  
 0.685
F31D5.2
Uncharacterized protein.
      
 0.662
T04A11.1
Uncharacterized protein.
      
 0.660
che-2
CHE-2 protein.
   
  
 0.650
wrt-9
WaRThog (Hedgehog-like family).
   
  
 0.611
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.