STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
skpo-3ShKT domain-containing protein. (1000 aa)    
Predicted Functional Partners:
ZK822.5
Uncharacterized protein; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
   
  
 0.903
F52H2.4
Uncharacterized protein; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
   
  
 0.892
doxa-1
Dual oxidase maturation factor 1; Plays a role in cuticle biogenesis. In complex with tsp-15 and the dual oxidase bli-3, promotes the generation of reactive oxygen species (ROS) and tyrosine cross-linking of collagen, thus stabilizing cuticular extracellular matrix.
   
  
 0.761
bli-5
Kunitz-type protein bli-5; Appears to lack serine protease inhibitor activity in vitro when tested with bovine pancreatic alpha-chymotrypsin and elastase. Involved in cuticle biosynthesis.
      
 0.695
tsp-15
Tetraspanin-15; Plays a role in cuticle biogenesis. In complex with doxa-1 and the dual oxidase bli-3, promotes the generation of reactive oxygen species (ROS) and tyrosine cross-linking of collagen, thus stabilizing cuticular extracellular matrix ; Belongs to the tetraspanin (TM4SF) family.
   
  
 0.672
bli-2
Col_cuticle_N domain-containing protein.
      
 0.666
mlt-7
Peroxidase mlt-7 heavy chain; Plays an essential role in cuticle biogenesis. Required in combination with bli-3 for correct formation of cross-links in cuticle collagens.
  
 
0.548
pxn-1
Peroxidasin homolog; Belongs to the peroxidase family. XPO subfamily.
  
 
 
0.521
skpo-1
Peroxidase skpo-1; Involved in hypodermal immune response against some types of bacterial infection. Probably utilizes H(2)O(2) produced by the NADPH oxidase bli-3. May play a role in cuticule biosynthesis. Belongs to the peroxidase family. XPO subfamily.
  
  
0.513
skpo-2
ShK domain and PerOxidase domain containing protein.
  
  
0.493
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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