STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F32B4.4Pharyngeal muscle protein 2; Involved in pharyngeal muscle development and ensures pharyngeal grinder function during feeding. Plays a role in the defense against the accumulation of ingested live pathogenic bacteria in the intestine. Has a role in the determination of life span. (1073 aa)    
Predicted Functional Partners:
F56H6.9
Uncharacterized protein.
      
 0.758
pamn-1
Probable peptidyl-glycine alpha-amidating monooxygenase pamn-1; Probable bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity; In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.
      
 0.700
pghm-1
Probable peptidylglycine alpha-hydroxylating monooxygenase 1; Monooxygenase that catalyzes an essential reaction in C- terminal alpha-amidation of peptides. Produces an unstable peptidyl(2- hydroxyglycine) intermediate. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity. Belongs to the copper type II ascorbate-dependent monooxygenase family.
      
 0.697
prpf-4
Protein kinase domain-containing protein.
   
    0.696
eat-17
Rab-GAP TBC domain-containing protein.
      
 0.696
eat-5
Innexin eat-5; Structural component of the gap junctions (By similarity). Required for synchronized pharyngeal muscle contractions. Belongs to the pannexin family.
      
 0.666
C50D2.8
Uncharacterized protein.
   
    0.645
eat-18
Uncharacterized protein.
      
 0.620
pop-1
Protein pop-1; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape. Represses expression of target genes via its interaction with hda-1 histone deacetylase. Required for specification of the M lineage-derived coelomocyte and sex myoblast fate. Regulates coelomocyte fate by positively regulating proliferation and ceh-34 and possibly eya-1 expression in M.dlpa and M.drpa precursors.
   
 
 0.562
clec-82
C-type lectin domain-containing protein.
      
 0.546
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.