STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tbc-3Rab-GAP TBC domain-containing protein. (495 aa)    
Predicted Functional Partners:
mon-2
Monensin-resistant homolog 2; May be required for traffic between late Golgi and early endosomes.
   
  
 0.931
ipla-1
DDHD domain-containing protein.
   
  
 0.859
mrps-6
Mitochondrial Ribosomal Protein, Small.
    
   0.796
rab-1
RAB family.
   
 
 0.783
acl-8
PlsC domain-containing protein.
   
  
 0.703
wrm-1
Armadillo repeat-containing protein wrm-1; Antagonistic role in the Wnt signaling pathway that operates in embryogenesis. When located at the cortex it has been shown to inhibit Wnt signaling during asymmetric cell division but when relocated to the nucleus it shows positive regulation. Has a role in blastomere signaling during endoderm specification. Activates lit-1- dependent kinase activity. Wrm-1/lit-1 complex promotes phosphorylation, down-regulation and subcellular relocation of pop-1. Can substitute for bar-1 indicating functional redundancy. Appears to have a role in centrosome [...]
   
  
 0.700
hrpu-2
Heterogeneous nuclear RibonucleoProtein U.
   
  
 0.699
rab-7
RAB family.
   
 
 0.683
acl-9
PlsC domain-containing protein.
   
  
 0.683
pad-1
Protein pad-1; May be involved in protein traffic between late Golgi and early endosomes (By similarity). Essential for cell patterning during gastrulation.
   
  
 0.668
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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