node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F09C12.2 | F32D8.1 | F09C12.2.1 | F32D8.1.1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.458 |
F21D5.3 | F32D8.1 | F21D5.3a.2 | F32D8.1.1 | Plastocyanin-like domain-containing protein. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.435 |
F32D8.1 | F09C12.2 | F32D8.1.1 | F09C12.2.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.458 |
F32D8.1 | F21D5.3 | F32D8.1.1 | F21D5.3a.2 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Plastocyanin-like domain-containing protein. | 0.435 |
F32D8.1 | T27C10.9 | F32D8.1.1 | T27C10.9.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Uncharacterized protein. | 0.587 |
F32D8.1 | cmd-1 | F32D8.1.1 | T21H3.3a.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. | 0.587 |
F32D8.1 | miro-1 | F32D8.1.1 | K08F11.5.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Mitochondrial Rho GTPase 1; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. | 0.463 |
F32D8.1 | mpk-2 | F32D8.1.1 | C04G6.1a.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.451 |
F32D8.1 | pmk-1 | F32D8.1.1 | B0218.3.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase pmk-1; Serine/threonine kinase which responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Phosphorylates snk-1 which probably regulates skn-1 nuclear translocation in response to oxidative stress. Probably by activating skn-1, involved in the up- regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacteria infection. Up-regulates expression of gcs-1 in intestinal cells upon arsenite treatment. Functions downstream of the MAPKK sek-1 and the MAPKKK nsy-1 as the MAP kinase [...] | 0.424 |
F32D8.1 | pmk-2 | F32D8.1.1 | F42G8.3a.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase pmk-2; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. | 0.438 |
F32D8.1 | pmk-3 | F32D8.1.1 | F42G8.4a.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase pmk-3; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. Involved in axon regeneration after injury, probably downstream of dlk-1 and mkk-4 and upstream of mak-2. May phosphorylate mak-2. Plays a role in cilium length regulation, possibly by reducing rab-5 mediated endocytosis. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. | 0.464 |
F32D8.1 | vps-41 | F32D8.1.1 | F32A6.3c.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane [...] | 0.497 |
T27C10.9 | F32D8.1 | T27C10.9.1 | F32D8.1.1 | Uncharacterized protein. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.587 |
cmd-1 | F32D8.1 | T21H3.3a.1 | F32D8.1.1 | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.587 |
miro-1 | F32D8.1 | K08F11.5.1 | F32D8.1.1 | Mitochondrial Rho GTPase 1; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.463 |
mpk-2 | F32D8.1 | C04G6.1a.1 | F32D8.1.1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.451 |
pmk-1 | F32D8.1 | B0218.3.1 | F32D8.1.1 | Mitogen-activated protein kinase pmk-1; Serine/threonine kinase which responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Phosphorylates snk-1 which probably regulates skn-1 nuclear translocation in response to oxidative stress. Probably by activating skn-1, involved in the up- regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacteria infection. Up-regulates expression of gcs-1 in intestinal cells upon arsenite treatment. Functions downstream of the MAPKK sek-1 and the MAPKKK nsy-1 as the MAP kinase [...] | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.424 |
pmk-1 | pmk-2 | B0218.3.1 | F42G8.3a.1 | Mitogen-activated protein kinase pmk-1; Serine/threonine kinase which responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Phosphorylates snk-1 which probably regulates skn-1 nuclear translocation in response to oxidative stress. Probably by activating skn-1, involved in the up- regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacteria infection. Up-regulates expression of gcs-1 in intestinal cells upon arsenite treatment. Functions downstream of the MAPKK sek-1 and the MAPKKK nsy-1 as the MAP kinase [...] | Mitogen-activated protein kinase pmk-2; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. | 0.908 |
pmk-1 | pmk-3 | B0218.3.1 | F42G8.4a.1 | Mitogen-activated protein kinase pmk-1; Serine/threonine kinase which responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Phosphorylates snk-1 which probably regulates skn-1 nuclear translocation in response to oxidative stress. Probably by activating skn-1, involved in the up- regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacteria infection. Up-regulates expression of gcs-1 in intestinal cells upon arsenite treatment. Functions downstream of the MAPKK sek-1 and the MAPKKK nsy-1 as the MAP kinase [...] | Mitogen-activated protein kinase pmk-3; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. Involved in axon regeneration after injury, probably downstream of dlk-1 and mkk-4 and upstream of mak-2. May phosphorylate mak-2. Plays a role in cilium length regulation, possibly by reducing rab-5 mediated endocytosis. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. | 0.914 |
pmk-2 | F32D8.1 | F42G8.3a.1 | F32D8.1.1 | Mitogen-activated protein kinase pmk-2; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.438 |