STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
snpc-4snRNA-activating protein complex subunit 4 homolog; Binds to the promoter regions of RNA polymerase II and III small-nuclear RNA genes, type 3 RNA polymerase III non-coding RNA genes, small nucleolar RNAs and transfer RNA genes. Required for expression of mature 21U-RNAs. (944 aa)    
Predicted Functional Partners:
snpc-1.1
SNAPc (Small Nuclear RNA Activating Complex) homolog.
   
 0.986
snpc-1.3
SNAPc (Small Nuclear RNA Activating Complex) homolog.
    
 0.985
snpc-3.2
SNAPc (Small Nuclear RNA Activating Complex) homolog.
   
 0.982
snpc-3.1
SNAPc (Small Nuclear RNA Activating Complex) homolog.
   
 0.974
prde-1
piRNA biogenesis factor prde-1; Nuclear factor required for the production of piwi- interacting RNA (piRNA) precursors. Specifically required for piRNAs produced from loci associated with the Ruby motif. Promotes binding of the transcription factor snpc-4 at piRNA genomic clusters. Required for normal fertility.
   
 
 0.967
tofu-4
Twenty One u-rna (21U-RNA) biogenesis Fouled Up.
   
  
 0.967
tofu-5
Twenty One u-rna (21U-RNA) biogenesis Fouled Up.
   
 
 0.924
gtf-2A2
Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.
    
  0.919
snpc-1.2
SNAPc (Small Nuclear RNA Activating Complex) homolog.
   
 0.882
snpc-3.4
SNAPc (Small Nuclear RNA Activating Complex) homolog.
   
 0.879
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.