node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F33H1.4 | T21F4.1 | F33H1.4.2 | T21F4.1.1 | Uncharacterized protein. | Uncharacterized protein; Belongs to the arginase family. | 0.465 |
F33H1.4 | apl-1 | F33H1.4.2 | C42D8.8a.1 | Uncharacterized protein. | Amyloid-beta-like protein; Required for normal developmental progression throughout all life stages. Specifically required for the molt stage during all larval transitions and morphogenesis. Acts with heterochronic genes, including members of the let-7 family, to regulate larval stage to adult transition. Acts synergistically with acn-1 in let-7 regulated postembryonic cell division of hypodermal seam cells. Acts in multiple pathways to influence daf-12 and daf-16 activity to in turn regulate physiological and reproductive processes such as body size and egg- laying. May play a role in [...] | 0.497 |
F33H1.4 | ced-9 | F33H1.4.2 | T07C4.8.1 | Uncharacterized protein. | Apoptosis regulator ced-9; Plays a major role in programmed cell death (PCD, apoptosis). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. During larval development, required for the elimination of transient presynaptic components downstream of egl-1 and upstream of ced-4 and ced-3 apoptotic pathway. | 0.547 |
F33H1.4 | daf-4 | F33H1.4.2 | C05D2.1a.2 | Uncharacterized protein. | Cell surface receptor daf-4; Involved in TGF-beta pathway. May be a receptor for daf-7. Controls the dauer/nondauer developmental decision in a range of environmental conditions. Regulates body size and male tail patterning. Involved in regulating entry into quiescence triggered by satiety. Involved in sensitivity to CO2 levels. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | 0.425 |
F33H1.4 | gpb-1 | F33H1.4.2 | F13D12.7a.1 | Uncharacterized protein. | Guanine nucleotide-binding protein subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. In the early embryo, controls the magnitude of the forces acting on centrosomes but is not required for generating asymmetric forces. | 0.409 |
F33H1.4 | gpc-1 | F33H1.4.2 | K02A4.2.3 | Uncharacterized protein. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.452 |
F33H1.4 | gpc-2 | F33H1.4.2 | F08B6.2.1 | Uncharacterized protein. | G protein gamma domain-containing protein. | 0.452 |
F33H1.4 | gsa-1 | F33H1.4.2 | R06A10.2a.1 | Uncharacterized protein. | G protein, Subunit Alpha. | 0.461 |
F33H1.4 | rpa-2 | F33H1.4.2 | M04F3.1.2 | Uncharacterized protein. | RPA_C domain-containing protein. | 0.481 |
F33H1.4 | rpa-4 | F33H1.4.2 | F59A3.6a.2 | Uncharacterized protein. | RPA_C domain-containing protein. | 0.464 |
T21F4.1 | F33H1.4 | T21F4.1.1 | F33H1.4.2 | Uncharacterized protein; Belongs to the arginase family. | Uncharacterized protein. | 0.465 |
apl-1 | F33H1.4 | C42D8.8a.1 | F33H1.4.2 | Amyloid-beta-like protein; Required for normal developmental progression throughout all life stages. Specifically required for the molt stage during all larval transitions and morphogenesis. Acts with heterochronic genes, including members of the let-7 family, to regulate larval stage to adult transition. Acts synergistically with acn-1 in let-7 regulated postembryonic cell division of hypodermal seam cells. Acts in multiple pathways to influence daf-12 and daf-16 activity to in turn regulate physiological and reproductive processes such as body size and egg- laying. May play a role in [...] | Uncharacterized protein. | 0.497 |
apl-1 | gpb-1 | C42D8.8a.1 | F13D12.7a.1 | Amyloid-beta-like protein; Required for normal developmental progression throughout all life stages. Specifically required for the molt stage during all larval transitions and morphogenesis. Acts with heterochronic genes, including members of the let-7 family, to regulate larval stage to adult transition. Acts synergistically with acn-1 in let-7 regulated postembryonic cell division of hypodermal seam cells. Acts in multiple pathways to influence daf-12 and daf-16 activity to in turn regulate physiological and reproductive processes such as body size and egg- laying. May play a role in [...] | Guanine nucleotide-binding protein subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. In the early embryo, controls the magnitude of the forces acting on centrosomes but is not required for generating asymmetric forces. | 0.637 |
apl-1 | gpc-1 | C42D8.8a.1 | K02A4.2.3 | Amyloid-beta-like protein; Required for normal developmental progression throughout all life stages. Specifically required for the molt stage during all larval transitions and morphogenesis. Acts with heterochronic genes, including members of the let-7 family, to regulate larval stage to adult transition. Acts synergistically with acn-1 in let-7 regulated postembryonic cell division of hypodermal seam cells. Acts in multiple pathways to influence daf-12 and daf-16 activity to in turn regulate physiological and reproductive processes such as body size and egg- laying. May play a role in [...] | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.592 |
apl-1 | gpc-2 | C42D8.8a.1 | F08B6.2.1 | Amyloid-beta-like protein; Required for normal developmental progression throughout all life stages. Specifically required for the molt stage during all larval transitions and morphogenesis. Acts with heterochronic genes, including members of the let-7 family, to regulate larval stage to adult transition. Acts synergistically with acn-1 in let-7 regulated postembryonic cell division of hypodermal seam cells. Acts in multiple pathways to influence daf-12 and daf-16 activity to in turn regulate physiological and reproductive processes such as body size and egg- laying. May play a role in [...] | G protein gamma domain-containing protein. | 0.578 |
ced-9 | F33H1.4 | T07C4.8.1 | F33H1.4.2 | Apoptosis regulator ced-9; Plays a major role in programmed cell death (PCD, apoptosis). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. During larval development, required for the elimination of transient presynaptic components downstream of egl-1 and upstream of ced-4 and ced-3 apoptotic pathway. | Uncharacterized protein. | 0.547 |
daf-4 | F33H1.4 | C05D2.1a.2 | F33H1.4.2 | Cell surface receptor daf-4; Involved in TGF-beta pathway. May be a receptor for daf-7. Controls the dauer/nondauer developmental decision in a range of environmental conditions. Regulates body size and male tail patterning. Involved in regulating entry into quiescence triggered by satiety. Involved in sensitivity to CO2 levels. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Uncharacterized protein. | 0.425 |
gpb-1 | F33H1.4 | F13D12.7a.1 | F33H1.4.2 | Guanine nucleotide-binding protein subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. In the early embryo, controls the magnitude of the forces acting on centrosomes but is not required for generating asymmetric forces. | Uncharacterized protein. | 0.409 |
gpb-1 | apl-1 | F13D12.7a.1 | C42D8.8a.1 | Guanine nucleotide-binding protein subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. In the early embryo, controls the magnitude of the forces acting on centrosomes but is not required for generating asymmetric forces. | Amyloid-beta-like protein; Required for normal developmental progression throughout all life stages. Specifically required for the molt stage during all larval transitions and morphogenesis. Acts with heterochronic genes, including members of the let-7 family, to regulate larval stage to adult transition. Acts synergistically with acn-1 in let-7 regulated postembryonic cell division of hypodermal seam cells. Acts in multiple pathways to influence daf-12 and daf-16 activity to in turn regulate physiological and reproductive processes such as body size and egg- laying. May play a role in [...] | 0.637 |
gpb-1 | gpc-1 | F13D12.7a.1 | K02A4.2.3 | Guanine nucleotide-binding protein subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. In the early embryo, controls the magnitude of the forces acting on centrosomes but is not required for generating asymmetric forces. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.996 |