STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
exc-7Uncharacterized protein. (456 aa)    
Predicted Functional Partners:
sup-12
RRM domain-containing protein.
  
 
 0.875
fox-1
Sex determination protein fox-1; A member of the sex determination pathway involved in making the distinction between one and two X-chromosomes. RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUG-3' elements. Regulates alternative splicing of tissue-specific exons. Promotes binding of sup-12 to target RNA.
  
 
 0.840
F31E3.2
Putative serine/threonine-protein kinase F31E3.2.
   
 
 0.837
sym-2
RNA-binding protein sym-2; mRNA splicing factor that regulates alternative splicing of many genes in embryo. Probably plays a role in the formation of embryo- specific isoforms; Belongs to the ESRP family.
   
 
 0.818
unc-16
JNK-interacting protein; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of synaptic vesicle transport, through interactions with the JNK-signaling components and motor proteins. Binds specific components of the JNK signaling pathway namely jnk-1, jkk-1 and sek-1. Associates with components of the motor protein, kinesin-1. Pre-assembled unc-16 scaffolding complexes are then transported as a cargo of kinesin, to the [...]
   
  
 0.813
mec-8
Mec-8 protein.
   
  
 0.812
hrpf-1
HnRNP F homolog.
   
 
 0.801
rsp-8
RRM domain-containing protein.
  
 
 0.794
mbl-1
Muscleblind-like protein; Binds to RNA with repeat sequences 5'-CUG-3' and 5'-CCUG-3'.
   
 
 0.748
H28G03.1
Uncharacterized protein.
   
 
 0.738
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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