STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
madf-2MADF domain-containing protein. (290 aa)    
Predicted Functional Partners:
nhr-156
Nuclear Hormone Receptor family.
    
 
 0.862
miz-1
SP-RING-type domain-containing protein.
    
 
 0.788
nhr-60
Nuclear hormone receptor family member nhr-60; Orphan nuclear receptor (Potential). Required for embryonic and larval morphogenesis and probably for seam cell positioning and migration; Belongs to the nuclear hormone receptor family.
   
 
 0.766
ceh-82
C. Elegans Homeobox.
   
  
 0.763
zip-8
bZIP transcription factor 8.
   
  
 0.749
zip-3
BZIP domain-containing protein.
      
 0.661
hpl-1
Heterochromatin protein 1 homolog.
   
 
 0.605
mre-11
Double-strand break repair protein mre-11; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. In response to ionizing radiation, probably required for the association between the brc-1-brd-1 heterodimer and rad-51 and let-70 in order to activate E3-ubiquitin ligase activity of the heterodimer and induce ubiquitination at DNA damage sites. Belongs to the MRE11/RAD32 family.
   
 
 0.585
far-5
Fatty Acid/Retinol binding protein.
    
 
 0.552
lim-7
LIM domain family.
    
 
 0.551
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.