node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
che-6 | cng-1 | C23H5.7.1 | F14H8.6b.1 | Cyclic nucleotide-binding domain-containing protein. | Cyclic nucleotide-binding domain-containing protein. | 0.638 |
che-6 | cng-2 | C23H5.7.1 | Y76B12C.1a.1 | Cyclic nucleotide-binding domain-containing protein. | Cyclic nucleotide-binding domain-containing protein. | 0.571 |
che-6 | cng-3 | C23H5.7.1 | F38E11.12.1 | Cyclic nucleotide-binding domain-containing protein. | Cyclic nucleotide-binding domain-containing protein. | 0.682 |
che-6 | tax-2 | C23H5.7.1 | F36F2.5.1 | Cyclic nucleotide-binding domain-containing protein. | Cyclic nucleotide-binding domain-containing protein. | 0.918 |
che-6 | tax-4 | C23H5.7.1 | ZC84.2.1 | Cyclic nucleotide-binding domain-containing protein. | Cyclic nucleotide-gated cation channel; Required for normal thermosensation and chemosensation sensory behavior. Required, downstream of receptor- type guanylate cyclase gcy-9, for CO2-mediated responses in BAG neurons. Required, downstream of receptor-type guanylate cyclase gcy-14, for alkaline pH-mediated responses in ASE-left (ASEL) neurons. Involved in the development of ASJ sensory neuron axon during late larval stages and in the maintenance of normal axon morphology in the adult. Regulates dauer formation. Required for the calcium flux to the cytoplasm in the ASJ sensory neurons [...] | 0.661 |
cng-1 | che-6 | F14H8.6b.1 | C23H5.7.1 | Cyclic nucleotide-binding domain-containing protein. | Cyclic nucleotide-binding domain-containing protein. | 0.638 |
cng-1 | cng-2 | F14H8.6b.1 | Y76B12C.1a.1 | Cyclic nucleotide-binding domain-containing protein. | Cyclic nucleotide-binding domain-containing protein. | 0.645 |
cng-1 | cng-3 | F14H8.6b.1 | F38E11.12.1 | Cyclic nucleotide-binding domain-containing protein. | Cyclic nucleotide-binding domain-containing protein. | 0.658 |
cng-1 | daf-11 | F14H8.6b.1 | B0240.3a.1 | Cyclic nucleotide-binding domain-containing protein. | Receptor-type guanylate cyclase daf-11; Guanylate cyclase involved in the production of the second messenger cGMP. In addition, regulates cGMP levels by controlling the transcription of 3',5'-cyclic phosphodiesterase pde-1 and pde-5 mRNAs. Involved in the olfactory, light and pheromone sensing pathways. Part of the chemosensory mechanism of the ASJ sensory neuron that controls dauer formation and dauer recovery. Promotes the calcium flux in ASJ sensory neurons in response to onset and removal of a nitric oxide (NO) stimulus and is thereby required for the behavioral avoidance response [...] | 0.720 |
cng-1 | gcy-8 | F14H8.6b.1 | C49H3.1.1 | Cyclic nucleotide-binding domain-containing protein. | Receptor-type guanylate cyclase gcy-8; Guanylate cyclase involved in the production of the second messenger cGMP. Regulates thermotaxis responses in AFD sensory neurons. May regulate AFD neuronal activity such as calcium responses to temperature gradients. Maintains the microvilli receptive ending morphology of the AFD thermosensory neurons by regulating cGMP levels downstream of kcc-3. cGMP levels antagonize the actin cytoskeleton regulator wsp-1. | 0.405 |
cng-1 | gpa-3 | F14H8.6b.1 | E02C12.5a.1 | Cyclic nucleotide-binding domain-containing protein. | Guanine nucleotide-binding protein alpha-3 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Promotes transcription of 3',5'-cyclic phosphodiesterases pde- 1 and pde-5, leading to reduced cGMP levels in sensory neurons. This causes suppression of insulin production and signaling which leads to increased daf-16 activity and contributes to increased adult lifespan and resistance to oxidative stress. In addition, by reducing cGMP levels, inhibits TGF-beta signaling pathways. Involved in behaviora [...] | 0.483 |
cng-1 | odr-1 | F14H8.6b.1 | R01E6.1b.1 | Cyclic nucleotide-binding domain-containing protein. | Receptor-type guanylate cyclase gcy-10; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward volatile odorants in AWC sensory neurons and their avoidance in AWB sensory neurons. May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP. Involved in phototransduction in ASJ neurons downstream of G protein coupled-photoreceptor lite-1. Required to maintain the expression of putative olfactory receptor str-2 in AWC neurons in adults. In AWB and AWC sensory neurons, media [...] | 0.720 |
cng-1 | odr-3 | F14H8.6b.1 | C34D1.3.1 | Cyclic nucleotide-binding domain-containing protein. | Guanine nucleotide-binding protein alpha-17 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. This specific G-alpha subunit plays an important role in olfaction and in cilia morphogenesis. Involved in chemotactic responses to attractants diacetyl, pyrazine, 2,4,5-trimethylthiazole, benzaldehyde, isoamyl alcohol, butanone and 2,3-pentanedione. Displays a redundant function with gpa-3 in chemotactic responses. Involved in avoidance responses to copper, sodium dodecyl sulfate and linoleic acid. I [...] | 0.766 |
cng-1 | tax-2 | F14H8.6b.1 | F36F2.5.1 | Cyclic nucleotide-binding domain-containing protein. | Cyclic nucleotide-binding domain-containing protein. | 0.917 |
cng-1 | tax-4 | F14H8.6b.1 | ZC84.2.1 | Cyclic nucleotide-binding domain-containing protein. | Cyclic nucleotide-gated cation channel; Required for normal thermosensation and chemosensation sensory behavior. Required, downstream of receptor- type guanylate cyclase gcy-9, for CO2-mediated responses in BAG neurons. Required, downstream of receptor-type guanylate cyclase gcy-14, for alkaline pH-mediated responses in ASE-left (ASEL) neurons. Involved in the development of ASJ sensory neuron axon during late larval stages and in the maintenance of normal axon morphology in the adult. Regulates dauer formation. Required for the calcium flux to the cytoplasm in the ASJ sensory neurons [...] | 0.656 |
cng-2 | che-6 | Y76B12C.1a.1 | C23H5.7.1 | Cyclic nucleotide-binding domain-containing protein. | Cyclic nucleotide-binding domain-containing protein. | 0.571 |
cng-2 | cng-1 | Y76B12C.1a.1 | F14H8.6b.1 | Cyclic nucleotide-binding domain-containing protein. | Cyclic nucleotide-binding domain-containing protein. | 0.645 |
cng-2 | cng-3 | Y76B12C.1a.1 | F38E11.12.1 | Cyclic nucleotide-binding domain-containing protein. | Cyclic nucleotide-binding domain-containing protein. | 0.661 |
cng-2 | daf-11 | Y76B12C.1a.1 | B0240.3a.1 | Cyclic nucleotide-binding domain-containing protein. | Receptor-type guanylate cyclase daf-11; Guanylate cyclase involved in the production of the second messenger cGMP. In addition, regulates cGMP levels by controlling the transcription of 3',5'-cyclic phosphodiesterase pde-1 and pde-5 mRNAs. Involved in the olfactory, light and pheromone sensing pathways. Part of the chemosensory mechanism of the ASJ sensory neuron that controls dauer formation and dauer recovery. Promotes the calcium flux in ASJ sensory neurons in response to onset and removal of a nitric oxide (NO) stimulus and is thereby required for the behavioral avoidance response [...] | 0.733 |
cng-2 | gcy-8 | Y76B12C.1a.1 | C49H3.1.1 | Cyclic nucleotide-binding domain-containing protein. | Receptor-type guanylate cyclase gcy-8; Guanylate cyclase involved in the production of the second messenger cGMP. Regulates thermotaxis responses in AFD sensory neurons. May regulate AFD neuronal activity such as calcium responses to temperature gradients. Maintains the microvilli receptive ending morphology of the AFD thermosensory neurons by regulating cGMP levels downstream of kcc-3. cGMP levels antagonize the actin cytoskeleton regulator wsp-1. | 0.438 |