STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hrg-4Heme transporter hrg-4; Heme transporter that mediates heme uptake across the plasma membrane; Belongs to the HRG family. (184 aa)    
Predicted Functional Partners:
hrg-3
Heme Responsive protein.
   
  
 0.901
hrg-2
Cadmium-inducible lysosomal protein CDR-5.
   
  
 0.841
mrp-5
Uncharacterized protein.
   
  
 0.812
Y37A1A.2
Uncharacterized protein.
      
 0.807
hpo-26
Uncharacterized protein.
      
 0.805
F22B5.4
Uncharacterized protein.
      
 0.803
hrg-7
Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.
   
  
 0.792
fre-1
NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of the anamorsin/DRE2 homolog. Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family. In the N-terminal section; belongs to the flavodoxin family.
      
 0.759
mics-1
Mitochondrial scaffolding protein 1; Plays a role in the regulation of lifespan in a partially daf-16-mediated manner, and may be involved in regulating the levels of reactive oxygen species production in response to heat stress.
      
 0.699
H02F09.2
Uncharacterized protein.
      
 0.695
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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