node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F36H2.3 | ash-2 | F36H2.3h.1 | Y17G7B.2d.1 | Uncharacterized protein. | Set1/Ash2 histone methyltransferase complex subunit ash-2; Component of the set-2/ash-2 histone methyltransferase (HMT) complex (Probable). Required for the di- and trimethylation at 'Lys-4' of histone H3, a mark associated with epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Functions as transcriptional regulator. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturat [...] | 0.697 |
F36H2.3 | atf-7 | F36H2.3h.1 | C07G2.2c.2 | Uncharacterized protein. | BZIP domain-containing protein. | 0.401 |
F36H2.3 | dpy-22 | F36H2.3h.1 | F47A4.2.1 | Uncharacterized protein. | Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Functio [...] | 0.412 |
F36H2.3 | egl-44 | F36H2.3h.1 | F28B12.2i.1 | Uncharacterized protein. | Transcription enhancer factor-like protein egl-44; Acts upstream of egl-46 to prevent touch cell differentiation in FLP neurons. Also promotes HSN neuron development. In association with egl-46, regulates cell cycle exit in the neuronal Q cell lineage. May be involved in thermal stress response downstream of yap-1. | 0.428 |
F36H2.3 | fos-1 | F36H2.3h.1 | F29G9.4b.1 | Uncharacterized protein. | Transcription factor fos-1; Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3'. [Isoform b]: Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 ; Belongs to the bZIP family. Fos subfamily. | 0.417 |
F36H2.3 | lys-1 | F36H2.3h.1 | Y22F5A.4.2 | Uncharacterized protein. | Lysozyme-like protein 1; Involved in resistance to Gram-negative bacterium S.marcescens and to bacterium Gram-positive S.aureus infection. | 0.552 |
F36H2.3 | rbbp-5 | F36H2.3h.1 | F21H12.1.1 | Uncharacterized protein. | Retinoblastoma-binding protein homolog 5; Required for di- and trimethylation at 'Lys-4' of histone H3. | 0.603 |
F36H2.3 | ubr-4 | F36H2.3h.1 | C44E4.1d.1 | Uncharacterized protein. | UBR-type domain-containing protein. | 0.476 |
F36H2.3 | utx-1 | F36H2.3h.1 | D2021.1a.1 | Uncharacterized protein. | UTX (Ubiquitously transcribed TPR on X) homolog. | 0.568 |
F36H2.3 | zfh-2 | F36H2.3h.1 | ZC123.3a.1 | Uncharacterized protein. | Zinc Finger and Homeobox. | 0.421 |
ash-2 | F36H2.3 | Y17G7B.2d.1 | F36H2.3h.1 | Set1/Ash2 histone methyltransferase complex subunit ash-2; Component of the set-2/ash-2 histone methyltransferase (HMT) complex (Probable). Required for the di- and trimethylation at 'Lys-4' of histone H3, a mark associated with epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Functions as transcriptional regulator. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturat [...] | Uncharacterized protein. | 0.697 |
ash-2 | dpy-22 | Y17G7B.2d.1 | F47A4.2.1 | Set1/Ash2 histone methyltransferase complex subunit ash-2; Component of the set-2/ash-2 histone methyltransferase (HMT) complex (Probable). Required for the di- and trimethylation at 'Lys-4' of histone H3, a mark associated with epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Functions as transcriptional regulator. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturat [...] | Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Functio [...] | 0.530 |
ash-2 | rbbp-5 | Y17G7B.2d.1 | F21H12.1.1 | Set1/Ash2 histone methyltransferase complex subunit ash-2; Component of the set-2/ash-2 histone methyltransferase (HMT) complex (Probable). Required for the di- and trimethylation at 'Lys-4' of histone H3, a mark associated with epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Functions as transcriptional regulator. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturat [...] | Retinoblastoma-binding protein homolog 5; Required for di- and trimethylation at 'Lys-4' of histone H3. | 0.999 |
ash-2 | utx-1 | Y17G7B.2d.1 | D2021.1a.1 | Set1/Ash2 histone methyltransferase complex subunit ash-2; Component of the set-2/ash-2 histone methyltransferase (HMT) complex (Probable). Required for the di- and trimethylation at 'Lys-4' of histone H3, a mark associated with epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Functions as transcriptional regulator. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturat [...] | UTX (Ubiquitously transcribed TPR on X) homolog. | 0.998 |
atf-7 | F36H2.3 | C07G2.2c.2 | F36H2.3h.1 | BZIP domain-containing protein. | Uncharacterized protein. | 0.401 |
atf-7 | egl-44 | C07G2.2c.2 | F28B12.2i.1 | BZIP domain-containing protein. | Transcription enhancer factor-like protein egl-44; Acts upstream of egl-46 to prevent touch cell differentiation in FLP neurons. Also promotes HSN neuron development. In association with egl-46, regulates cell cycle exit in the neuronal Q cell lineage. May be involved in thermal stress response downstream of yap-1. | 0.460 |
dpy-22 | F36H2.3 | F47A4.2.1 | F36H2.3h.1 | Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Functio [...] | Uncharacterized protein. | 0.412 |
dpy-22 | ash-2 | F47A4.2.1 | Y17G7B.2d.1 | Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Functio [...] | Set1/Ash2 histone methyltransferase complex subunit ash-2; Component of the set-2/ash-2 histone methyltransferase (HMT) complex (Probable). Required for the di- and trimethylation at 'Lys-4' of histone H3, a mark associated with epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Functions as transcriptional regulator. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturat [...] | 0.530 |
dpy-22 | rbbp-5 | F47A4.2.1 | F21H12.1.1 | Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Functio [...] | Retinoblastoma-binding protein homolog 5; Required for di- and trimethylation at 'Lys-4' of histone H3. | 0.599 |
dpy-22 | utx-1 | F47A4.2.1 | D2021.1a.1 | Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Functio [...] | UTX (Ubiquitously transcribed TPR on X) homolog. | 0.414 |