STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
srj-54Serpentine Receptor, class J. (328 aa)    
Predicted Functional Partners:
srd-1
Serpentine receptor class delta-1.
   
  
 0.815
lep-2
LEPtoderan male tail.
      
 0.811
srh-34
Serpentine Receptor, class H.
   
  
 0.705
mab-3
Protein male abnormal 3; Transcription factor which binds the DNA motif 5'- [CGA][TCA][TA]ACAATGT[AT][TGA]C-3', probably as a monomer. Acts partially redundantly with the transcription factor dmd-3 to coordinate tail tip cell fusion and retraction and thereby regulate male tail tip morphogenesis. Promotes male-specific development of two tissues, the peripheral nervous system and the intestine. In the peripheral nervous system, directs differentiation of sensory ray neuroblasts into peripheral sense organs. In the intestine, causes repression of vitellogenin gene transcription.
      
 0.694
dmd-5
DM domain-containing protein.
      
 0.692
dmd-3
Doublesex- and mab-3-related transcription factor dmd-3; Transcriptional activator which promotes male-specific development. Acts partially redundantly with the transcription factor mab-3 to coordinate tail tip cell fusion and retraction and thereby regulate male tail tip morphogenesis. This is most likely through the regulation of downstream effectors such as eff-1. May also negatively regulate the expression of other proteins implicated in male tail morphogenesis including nhr-25, vav-1 and arl-1 in tail tip cells. In males, plays a role in the development of ray A-neurons by negativ [...]
      
 0.665
tra-1
Sex-determining transformer protein 1; Plays a major role in controlling sexual phenotype. Terminal global regulator in a well-characterized cascade of sex-determining genes. Promotes female development. Interacts with tra-2 to promote spermatogenesis. Promotes spermatogenesis through the Tip60 HAT complex and by regulating the expression of genes, such as fog-3, required for male development (By similarity). Association with chromatin and at the fog-3 promoter requires wdr-5.1, and may also require wdr-5.2. With trr-1, activates the fog-3 gene to determine sperm/oocyte cell fate (By s [...]
      
 0.588
srx-16
G_PROTEIN_RECEP_F1_2 domain-containing protein.
   
    0.580
srm-1
Serpentine Receptor, class M.
   
  
 0.578
srx-6
G_PROTEIN_RECEP_F1_2 domain-containing protein.
   
    0.569
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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