STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mec-14Aldo_ket_red domain-containing protein. (453 aa)    
Predicted Functional Partners:
npp-11
Nuclear Pore complex Protein.
   
 
 0.989
npp-15
Nuclear pore complex protein 15; Important for early nematode development. Belongs to the nucleoporin Nup133 family.
   
 
 0.902
npp-5
Nuclear pore complex protein 5; Involved in kinetochore assembly and chromosome segregation during embryonic mitosis. Required for the localization of the NDC80 complex member him-10, the chromosomal passenger complex component air- 2 and nuclear pore complex proteins npp-23 and npp-15 to kinetochores during metaphase. Required for npp-23 localization to the nuclear envelope during interphase. Recruits mdf-1, a component of the spindle assembly checkpoint, to the nuclear envelope. Appears dispensable for the assembly of the nuclear pore complex and for nuclear protein import.
   
 
 0.892
mec-18
Uncharacterized protein.
   
 
 0.891
npp-20
Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution. Belongs to the WD repeat SEC13 family.
    
 
 0.866
C34C6.4
Uncharacterized protein.
    
 0.838
dyf-6
Intraflagellar transport protein 46 homolog; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility. Required for normal morphology and function of ciliated amphid sensory neurons.
    
 0.838
agxt-1
Serine--pyruvate aminotransferase.
  
 
  0.824
F10G8.9
PKS_KS domain-containing protein; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
   
 
 0.810
mec-1
Uncharacterized protein.
      
 0.808
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.