STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
comp-1Protein kinase domain-containing protein. (419 aa)    
Predicted Functional Partners:
htas-1
Histone H2A; Belongs to the histone H2A family.
   
  
 0.872
gsp-3
Serine/threonine-protein phosphatase PP1-gamma; Probable phosphatase which plays a redundant role with gsp-4 in spermatogenesis by regulating sister chromatid segregation during meiosis. In addition, involved in sperm motility by controlling the dynamic disassembly of major sperm proteins (MSP) in the spermatozoan pseudopodium.
   
  
 0.858
spe-8
Spermatocyte protein spe-8; Probable non-receptor tyrosine-protein kinase which plays a role in spermatid activation (spermiogenesis) in hermaphrodites.
   
  
 0.767
K01H12.4
Uncharacterized protein.
   
    0.720
spe-11
Spermatocyte protein spe-11; Paternally sperm-supplied factor required for embryogenesis. Plays a role in preventing polyspermy possibly by promoting the formation of a continuous and cohesive eggshell chitin layer.
   
  
 0.715
srb-13
Serpentine receptor class beta-13; G-protein coupled receptor that antagonizes the negative effects of the gcy-35 oxygen sensor on spermatogenesis. This leads to the maintenance of mitochondrial function in developing spermatocytes and/or spermatids prior to testis maturation during the early larval stages. Regulates the navigational capacity of sperm during hyperoxic conditions ensuring the proper targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites. May act in the same signaling pathway as the neuropeptide flp-21.
   
  
 0.697
B0218.7
Uncharacterized protein.
   
    0.641
smz-2
Sperm Meiosis PDZ domain containing proteins.
   
    0.641
K07A1.4
Uncharacterized protein.
   
    0.637
F31E8.5
Uncharacterized protein.
   
    0.635
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.