STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sup-36SUPpressor. (169 aa)    
Predicted Functional Partners:
sup-37
SUPpressor.
      
 0.962
sup-35
SUPpressor.
   
  
 0.913
ubc-18
UBIQUITIN_CONJUGAT_2 domain-containing protein.
      
 0.852
pha-1
Pha-1 protein.
      
 0.741
ptl-1
Microtubule-associated protein.
    
 
 0.713
lin-35
Retinoblastoma-like protein homolog lin-35; Key regulator of cell division which acts as a transcriptional repressor and negatively regulates cell cycle progression in its active unphosphorylated form, but allows cell cycle progression when phosphorylated. When unphosphorylated and in its active form, interacts with E2F transcription factors such as efl-1 to repress their transcriptional activity and negatively regulate the progression through the G1 phase of the cell cycle during postembryonic development. May furthermore act with cell cycle regulator cki-1 to negatively regulate cell [...]
      
 0.691
Y47D3A.1
Uncharacterized protein.
   
  
 0.670
fbxa-128
FTH domain-containing protein.
      
 0.660
fbxc-53
F-box C protein.
    
   0.624
skp-1
Uncharacterized protein T27F2.1.
   
  
 0.591
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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