STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ech-2Enoyl-CoA Hydratase. (297 aa)    
Predicted Functional Partners:
ivd-1
Isovaleryl-CoA dehydrogenase.
   
 
 0.852
acd-2
Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
      
 0.807
acd-4
Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
      
 0.807
T20H4.5
Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
   
  
 0.708
acd-5
Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
      
 0.700
sod-4
Extracellular superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family.
      
 0.670
rib-1
Exostosin-1 homolog; Required for the biosynthesis of heparan sulfate by positively regulating N-acetylglucosamine transferase II (GlcNAcT-II) and glucuronyl transferase II (GlcAT-II) activities of glycosyltransferase rib-2. Probably not directly involved in chondroitin sulfate biosynthesis but negatively regulates chondroitin sulfate levels. Maternally required for normal ventral epidermal enclosure and for embryo elongation during the early stages of embryonic development. In addition, involved in the elongation of the pharyngeal isthmus and in the organization of the actin cytoskele [...]
 
      0.610
acs-19
Acetyl-coenzyme A synthetase.
   
  
 0.592
madd-3
Probable dual specificity protein kinase madd-3; [Isoform a]: Probable dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Negatively regulates p38 MAPK signaling to allow for the plasma membrane of body wall muscle cells to form projections, also called muscle arms, that extend and connect the body wall muscles to target motor neurons. Negative regulation of p38 MAPK signaling may in turn modulate the trafficking of the muscle specific receptor eva-1 to the lysosome, to ensure proper display of the eva-1 receptor on the plasma membrane of muscle [...]
 
      0.588
B0272.4
Uncharacterized protein B0272.4.
  
 
 0.564
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.