STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tig-2TGF_BETA_2 domain-containing protein. (366 aa)    
Predicted Functional Partners:
sma-6
Serine/threonine-protein kinase sma-6; Involved in TGF-beta pathway. May be a receptor for daf-7; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
   
 0.885
tig-3
TGF_BETA_2 domain-containing protein.
     
 0.884
tag-68
Dwarfin sma.
   
 0.876
daf-14
MH2 domain-containing protein.
  
 
 0.857
daf-1
Cell surface receptor daf-1; Controls the dauer/nondauer developmental decision in a range of environmental conditions. Involved in regulating entry into quiescence triggered by satiety. Involved in sensitivity to CO2 levels.
   
 0.857
daf-8
Dwarfin sma.
  
 
 0.857
daf-4
Cell surface receptor daf-4; Involved in TGF-beta pathway. May be a receptor for daf-7. Controls the dauer/nondauer developmental decision in a range of environmental conditions. Regulates body size and male tail patterning. Involved in regulating entry into quiescence triggered by satiety. Involved in sensitivity to CO2 levels. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
   
 0.824
sma-3
Dwarfin sma-3; Involved in TGF-beta pathway. Plays a role in male tail tip morphogenesis ; Belongs to the dwarfin/SMAD family.
  
 
 0.762
sma-2
Dwarfin sma-2; Involved in TGF-beta pathway. Plays a role in male tail tip morphogenesis.
  
 
 0.752
daf-3
Dwarfin sma.
   
 0.737
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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