STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
nipi-4Protein nipi-4; Pseudokinase which plays a role in resistance to fungal infection by promoting expression of antimicrobial peptides (nlp-29, nlp-31, nlp-34, cnc-1, cnc-2 and cnc-4) in the epidermis. In addition, up-regulates nlp-29 expression upon physical wounding and in response to phorbol ester PMA treatment; Belongs to the protein kinase superfamily. Tyr protein kinase family. (396 aa)    
Predicted Functional Partners:
sli-1
Suppressor of LIneage defect.
    
 0.937
sem-5
Sex muscle abnormal protein 5; Adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as egl-15 and let-23 probably acting upstream of let-60/ras. Negatively regulates vulva induction probably downstream of let-23. Involved in sex myoblast migration. Negatively regulates fluid homeostasis probably downstream of egl-15. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of egl- 15. Involved in cytoskeleton dynamics and is recruited by mig-13 to the [...]
    
 
 0.876
shc-1
SHC-transforming protein homolog 1; Scaffold protein which plays an important role in the activation of the JNK pathway composed of mlk-1, mek-1 and kgb-1; by bringing together mek-1 and mlk-1, promotes mlk-1-mediated phosphorylation and activation of mek-1 which in turn phosphorylates kgb-1. In addition, negatively modulates the activation of the insulin/IGF-1-like signaling (IIS) probably by inhibiting the insulin receptor daf-2. Positively regulates the activity of the transcription factor daf-16/FOXO by both inhibiting IIS and activating the JNK pathway. Involved in the response to [...]
    
 
 0.824
tns-1
Tensin homolog; Probable phosphatase which regulates axon regeneration after injury by linking the svh-2 and integrin signaling pathways.
   
 
 0.815
Y47G6A.13
Protein kinase domain-containing protein.
      
 0.810
ptp-2
Tyrosine-protein phosphatase non-receptor type ptp-2; Involved in embryonic and larval development. Plays a role in oogenesis by regulating mpk-1 phosphorylation and oocyte maturation in response to major sperm protein (MSP). During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of receptor egl-15. Plays a role in fluid homeostasis probably downstream of receptor egl-15 and adapter soc-1. Promotes vulva induction and negatively regulates fertility probably downstream of receptor let-23. N [...]
    
 
 0.802
ced-2
Cell death abnormality protein 2; Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Has a role in the migration of the 2 gonadal distal tip cells (DTCs).
    
 0.726
snf-12
Transporter.
   
  
 0.717
tpa-1
Protein kinase C-like 1; Diacylglycerol (DAG)-dependent serine/threonine-protein kinase that phosphorylates a range of cellular proteins (Probable). Phosphorylates mlk-1, a component of the JNK pathway. Involved in axon regeneration after injury probably by activating the JNK pathway. Plays a role in resistance to fungal infection and in wound healing by promoting expression of antimicrobial peptide nlp- 29 in the epidermis downstream of gpa-12 and plc-3 and upstream of tir- 1-p38-like pathway. Probably by regulating neuronal transmission in ALA neurons, regulates the decrease in phary [...]
   
 
 0.698
gap-3
GTPase Activating Protein family.
    
 0.682
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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