STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hch-1Zinc metalloproteinase nas-34; Metalloprotease (By similarity). Required for normal hatching and migration of neuroblasts. May act by degrading eggshell proteins at hatching (605 aa)    
Predicted Functional Partners:
col-121
COLlagen; Protein COL-121 (col-121) mRNA, complete cds
   
   0.747
dpy-17
DumPY: shorter than wild-type; Protein DPY-17 (dpy-17) mRNA, complete cds
   
   0.685
ces-2
Cell death specification protein 2; Required to activate programmed cell death in the sister cells of the serotoninergic neurosecretory motor (NSM) neurons. Negatively regulates the activity of ces-1 which in turn negatively regulates the activities of cell-killing genes. Binds to the DNA sequence 5'-RTTACGTAAY-3'
   
    0.685
dpy-14
DumPY: shorter than wild-type; Protein DPY-14 (dpy-14) mRNA, complete cds
   
   0.668
rpl-1
60S ribosomal protein L10a; Protein RPL-1, isoform a; Belongs to the universal ribosomal protein uL1 family
      
 0.649
tsp-1
Tetraspanin-1; Protein TSP-1 (tsp-1) mRNA, complete cds
      
 0.640
K08B4.2
Protein K08B4.2 (K08B4.2) mRNA, complete cds
   
    0.542
cutl-2
CUTiclin-Like; Protein CUTL-2 (cutl-2) mRNA, complete cds
   
    0.534
clec-266
C-type LECtin; Protein CLEC-266, isoform c
   
    0.533
Y41D4B.26
Protein Y41D4B.26 (Y41D4B.26) mRNA, complete cds
   
    0.524
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Caenorhabditis elegans, Rhabditis elegans, roundworm
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