STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hch-1Zinc metalloproteinase nas-34; Metalloprotease (By similarity). Required for normal hatching and migration of neuroblasts. May act by degrading eggshell proteins at hatching. (605 aa)    
Predicted Functional Partners:
Y45F10C.4
UPF0375 protein Y45F10C.4.
      
 0.912
Y45F10C.2
UPF0375 protein Y45F10C.2; Negatively regulates the egg-laying rate by promoting retention of fertilized eggs.
   
  
 0.851
tsp-1
Tetraspanin-1.
   
  
 0.663
col-121
Col_cuticle_N domain-containing protein.
   
    0.629
dpy-14
Col_cuticle_N domain-containing protein.
   
   0.622
noah-2
NOmpA Homolog (Drosophila nompA: no mechanoreceptor potential A).
   
  
 0.603
nas-3
Zinc metalloproteinase nas-3; Metalloprotease.
  
   
 0.595
Y41D4B.26
Uncharacterized protein.
   
    0.592
nas-2
Zinc metalloproteinase nas-2; Metalloprotease.
  
   
 0.588
sym-1
SYM-1 protein.
   
  
 0.563
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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