STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F40F8.1UMP-CMP kinase 2; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (228 aa)    
Predicted Functional Partners:
rnr-1
Ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
  
 
 0.962
dut-1
Deoxyuridinetriphosphatase.
  
 0.959
C47B2.2
Uncharacterized protein.
  
 
 0.955
F19B6.1
Uridine kinase; Belongs to the uridine kinase family.
  
 
 0.951
ndk-1
Nucleoside diphosphate kinase; Belongs to the NDK family.
  
 
 0.951
R05G6.5
Uncharacterized protein.
  
 
 0.951
umps-1
Orotidine 5'-phosphate decarboxylase; Bifunctional enzyme which catalyzes the formation of UMP from orotate in the de novo pathway of pyrimidine biosynthesis. May also form UMP from uracil. Regulates the size of gut granules during embryonic development. Involved in resistance to DNA damaging agents including UV-C and X-ray radiation. In the C-terminal section; belongs to the OMP decarboxylase family.
   
 
 0.950
B0001.4
Probable uridine-cytidine kinase; Belongs to the uridine kinase family.
  
 
 0.947
rnr-2
Ribonucleoside-diphosphate reductase small chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
   
 
 0.937
thk-1
Thymidine kinase.
   
 
 0.925
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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