node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ZK430.5 | aspm-1 | ZK430.5.1 | C45G3.1.1 | Peptidase C50 domain-containing protein. | Calponin-homology (CH) domain-containing protein. | 0.806 |
ZK430.5 | bir-1 | ZK430.5.1 | T27F2.3.1 | Peptidase C50 domain-containing protein. | Chromosomal passenger complex protein bir-1; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis. The CPC complex has essential functions at the centromere in ensuring correct chromosome condensation, alignment and segregation. In the complex, required to direct the Aurora B/air-2 kinase to chromosomes. Also functions in spindle midzone formation and in the formation of polar bodies during oogenesis. Required for the localization of the kinetochore component hcp-1 to chromosomes. Involved in the positive [...] | 0.767 |
ZK430.5 | bir-2 | ZK430.5.1 | C50B8.2.1 | Peptidase C50 domain-containing protein. | Baculoviral IAP repeat-containing protein bir-2. | 0.575 |
ZK430.5 | bmk-1 | ZK430.5.1 | F23B12.8b.1 | Peptidase C50 domain-containing protein. | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.833 |
ZK430.5 | fkh-8 | ZK430.5.1 | F40H3.4b.2 | Peptidase C50 domain-containing protein. | Fork-head domain-containing protein. | 0.731 |
ZK430.5 | pig-1 | ZK430.5.1 | W03G1.6c.1 | Peptidase C50 domain-containing protein. | Maternal embryonic leucine zipper kinase; Serine/threonine-protein kinase involved in cell autonomous neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell by controlling spindle positioning, myosin distribution and the segregation of cell fate determinants. Promotes cell shedding during embryogenesis, probably through the endocytosis-mediated removal of cell adhesion molecules such as hmp-1 from the cell surface. May act downstream of par-4/strd-1/mop-25 to regulate cell shedding. | 0.496 |
ZK430.5 | spd-1 | ZK430.5.1 | Y34D9A.4.1 | Peptidase C50 domain-containing protein. | SPD-1. | 0.538 |
aspm-1 | ZK430.5 | C45G3.1.1 | ZK430.5.1 | Calponin-homology (CH) domain-containing protein. | Peptidase C50 domain-containing protein. | 0.806 |
aspm-1 | bir-1 | C45G3.1.1 | T27F2.3.1 | Calponin-homology (CH) domain-containing protein. | Chromosomal passenger complex protein bir-1; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis. The CPC complex has essential functions at the centromere in ensuring correct chromosome condensation, alignment and segregation. In the complex, required to direct the Aurora B/air-2 kinase to chromosomes. Also functions in spindle midzone formation and in the formation of polar bodies during oogenesis. Required for the localization of the kinetochore component hcp-1 to chromosomes. Involved in the positive [...] | 0.819 |
aspm-1 | bir-2 | C45G3.1.1 | C50B8.2.1 | Calponin-homology (CH) domain-containing protein. | Baculoviral IAP repeat-containing protein bir-2. | 0.632 |
aspm-1 | bmk-1 | C45G3.1.1 | F23B12.8b.1 | Calponin-homology (CH) domain-containing protein. | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.988 |
aspm-1 | fkh-8 | C45G3.1.1 | F40H3.4b.2 | Calponin-homology (CH) domain-containing protein. | Fork-head domain-containing protein. | 0.758 |
aspm-1 | mcm-5 | C45G3.1.1 | R10E4.4.2 | Calponin-homology (CH) domain-containing protein. | DNA replication licensing factor mcm-5; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentia [...] | 0.579 |
aspm-1 | pig-1 | C45G3.1.1 | W03G1.6c.1 | Calponin-homology (CH) domain-containing protein. | Maternal embryonic leucine zipper kinase; Serine/threonine-protein kinase involved in cell autonomous neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell by controlling spindle positioning, myosin distribution and the segregation of cell fate determinants. Promotes cell shedding during embryogenesis, probably through the endocytosis-mediated removal of cell adhesion molecules such as hmp-1 from the cell surface. May act downstream of par-4/strd-1/mop-25 to regulate cell shedding. | 0.840 |
aspm-1 | sep-1 | C45G3.1.1 | Y47G6A.12.2 | Calponin-homology (CH) domain-containing protein. | Separin homolog sep-1; Cysteine protease, which plays a central role in homologous chromosome separation during meiosis I and in sister chromatid separation during embryonic mitosis. Promotes chromosome/sister chromatid segregation by cleaving the scc-1 (mitosis) and rec-8 (meiosis) subunits of the cohesin complex at the onset of anaphase (Probable). May cleave histone H3-like protein cpar-1 during meiosis I metaphase- anaphase transition. Promotes cortical granule exocytosis after oocyte fertilization during the first meiotic anaphase. Essential for embryonic cytokinesis by regulating [...] | 0.871 |
aspm-1 | spd-1 | C45G3.1.1 | Y34D9A.4.1 | Calponin-homology (CH) domain-containing protein. | SPD-1. | 0.936 |
bir-1 | ZK430.5 | T27F2.3.1 | ZK430.5.1 | Chromosomal passenger complex protein bir-1; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis. The CPC complex has essential functions at the centromere in ensuring correct chromosome condensation, alignment and segregation. In the complex, required to direct the Aurora B/air-2 kinase to chromosomes. Also functions in spindle midzone formation and in the formation of polar bodies during oogenesis. Required for the localization of the kinetochore component hcp-1 to chromosomes. Involved in the positive [...] | Peptidase C50 domain-containing protein. | 0.767 |
bir-1 | aspm-1 | T27F2.3.1 | C45G3.1.1 | Chromosomal passenger complex protein bir-1; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis. The CPC complex has essential functions at the centromere in ensuring correct chromosome condensation, alignment and segregation. In the complex, required to direct the Aurora B/air-2 kinase to chromosomes. Also functions in spindle midzone formation and in the formation of polar bodies during oogenesis. Required for the localization of the kinetochore component hcp-1 to chromosomes. Involved in the positive [...] | Calponin-homology (CH) domain-containing protein. | 0.819 |
bir-1 | bir-2 | T27F2.3.1 | C50B8.2.1 | Chromosomal passenger complex protein bir-1; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis. The CPC complex has essential functions at the centromere in ensuring correct chromosome condensation, alignment and segregation. In the complex, required to direct the Aurora B/air-2 kinase to chromosomes. Also functions in spindle midzone formation and in the formation of polar bodies during oogenesis. Required for the localization of the kinetochore component hcp-1 to chromosomes. Involved in the positive [...] | Baculoviral IAP repeat-containing protein bir-2. | 0.910 |
bir-1 | bmk-1 | T27F2.3.1 | F23B12.8b.1 | Chromosomal passenger complex protein bir-1; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis. The CPC complex has essential functions at the centromere in ensuring correct chromosome condensation, alignment and segregation. In the complex, required to direct the Aurora B/air-2 kinase to chromosomes. Also functions in spindle midzone formation and in the formation of polar bodies during oogenesis. Required for the localization of the kinetochore component hcp-1 to chromosomes. Involved in the positive [...] | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.806 |