node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
D1054.3 | phlp-2 | D1054.3a.1 | F43C1.1.1 | SGS domain-containing protein. | Protein phosphatase PHLPP-like protein; Probable protein phosphatase. | 0.914 |
Y65B4A.4 | phlp-2 | Y65B4A.4.1 | F43C1.1.1 | Uncharacterized protein. | Protein phosphatase PHLPP-like protein; Probable protein phosphatase. | 0.824 |
akt-1 | akt-2 | C12D8.10b.2 | F28H6.1a.1 | Serine/threonine-protein kinase akt-1; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Has an essential role in regulating developmental arrest at the dauer stage. Plays a role in immune function and pathogen resistance. Regulates salt chemotaxis learning. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic devel [...] | Serine/threonine-protein kinase akt-2; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Essential role in regulating developmental arrest at the dauer stage. Phosphorylates Forkhead-related daf- 16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Role in immune function and pathogen resistance. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic development. Belongs to the protein kinase superfamily. [...] | 0.956 |
akt-1 | kin-2 | C12D8.10b.2 | R07E4.6c.1 | Serine/threonine-protein kinase akt-1; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Has an essential role in regulating developmental arrest at the dauer stage. Plays a role in immune function and pathogen resistance. Regulates salt chemotaxis learning. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic devel [...] | cAMP-dependent protein kinase regulatory subunit; Controls the rhythmic contraction of enteric muscles probably by regulating G-protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons; Belongs to the cAMP-dependent kinase regulatory chain family. | 0.864 |
akt-1 | phlp-2 | C12D8.10b.2 | F43C1.1.1 | Serine/threonine-protein kinase akt-1; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Has an essential role in regulating developmental arrest at the dauer stage. Plays a role in immune function and pathogen resistance. Regulates salt chemotaxis learning. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic devel [...] | Protein phosphatase PHLPP-like protein; Probable protein phosphatase. | 0.895 |
akt-2 | akt-1 | F28H6.1a.1 | C12D8.10b.2 | Serine/threonine-protein kinase akt-2; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Essential role in regulating developmental arrest at the dauer stage. Phosphorylates Forkhead-related daf- 16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Role in immune function and pathogen resistance. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic development. Belongs to the protein kinase superfamily. [...] | Serine/threonine-protein kinase akt-1; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Has an essential role in regulating developmental arrest at the dauer stage. Plays a role in immune function and pathogen resistance. Regulates salt chemotaxis learning. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic devel [...] | 0.956 |
akt-2 | kin-2 | F28H6.1a.1 | R07E4.6c.1 | Serine/threonine-protein kinase akt-2; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Essential role in regulating developmental arrest at the dauer stage. Phosphorylates Forkhead-related daf- 16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Role in immune function and pathogen resistance. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic development. Belongs to the protein kinase superfamily. [...] | cAMP-dependent protein kinase regulatory subunit; Controls the rhythmic contraction of enteric muscles probably by regulating G-protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons; Belongs to the cAMP-dependent kinase regulatory chain family. | 0.897 |
akt-2 | phlp-2 | F28H6.1a.1 | F43C1.1.1 | Serine/threonine-protein kinase akt-2; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Essential role in regulating developmental arrest at the dauer stage. Phosphorylates Forkhead-related daf- 16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Role in immune function and pathogen resistance. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic development. Belongs to the protein kinase superfamily. [...] | Protein phosphatase PHLPP-like protein; Probable protein phosphatase. | 0.868 |
cas-1 | kin-2 | F41G4.2a.1 | R07E4.6c.1 | Adenylyl cyclase-associated protein; Belongs to the CAP family. | cAMP-dependent protein kinase regulatory subunit; Controls the rhythmic contraction of enteric muscles probably by regulating G-protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons; Belongs to the cAMP-dependent kinase regulatory chain family. | 0.443 |
cas-1 | phlp-2 | F41G4.2a.1 | F43C1.1.1 | Adenylyl cyclase-associated protein; Belongs to the CAP family. | Protein phosphatase PHLPP-like protein; Probable protein phosphatase. | 0.917 |
cas-2 | kin-2 | C18E3.6a.2 | R07E4.6c.1 | Adenylyl cyclase-associated protein; Belongs to the CAP family. | cAMP-dependent protein kinase regulatory subunit; Controls the rhythmic contraction of enteric muscles probably by regulating G-protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons; Belongs to the cAMP-dependent kinase regulatory chain family. | 0.426 |
cas-2 | phlp-2 | C18E3.6a.2 | F43C1.1.1 | Adenylyl cyclase-associated protein; Belongs to the CAP family. | Protein phosphatase PHLPP-like protein; Probable protein phosphatase. | 0.917 |
kin-2 | akt-1 | R07E4.6c.1 | C12D8.10b.2 | cAMP-dependent protein kinase regulatory subunit; Controls the rhythmic contraction of enteric muscles probably by regulating G-protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons; Belongs to the cAMP-dependent kinase regulatory chain family. | Serine/threonine-protein kinase akt-1; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Has an essential role in regulating developmental arrest at the dauer stage. Plays a role in immune function and pathogen resistance. Regulates salt chemotaxis learning. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic devel [...] | 0.864 |
kin-2 | akt-2 | R07E4.6c.1 | F28H6.1a.1 | cAMP-dependent protein kinase regulatory subunit; Controls the rhythmic contraction of enteric muscles probably by regulating G-protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons; Belongs to the cAMP-dependent kinase regulatory chain family. | Serine/threonine-protein kinase akt-2; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Essential role in regulating developmental arrest at the dauer stage. Phosphorylates Forkhead-related daf- 16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Role in immune function and pathogen resistance. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic development. Belongs to the protein kinase superfamily. [...] | 0.897 |
kin-2 | cas-1 | R07E4.6c.1 | F41G4.2a.1 | cAMP-dependent protein kinase regulatory subunit; Controls the rhythmic contraction of enteric muscles probably by regulating G-protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons; Belongs to the cAMP-dependent kinase regulatory chain family. | Adenylyl cyclase-associated protein; Belongs to the CAP family. | 0.443 |
kin-2 | cas-2 | R07E4.6c.1 | C18E3.6a.2 | cAMP-dependent protein kinase regulatory subunit; Controls the rhythmic contraction of enteric muscles probably by regulating G-protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons; Belongs to the cAMP-dependent kinase regulatory chain family. | Adenylyl cyclase-associated protein; Belongs to the CAP family. | 0.426 |
kin-2 | pde-4 | R07E4.6c.1 | R153.1d.1 | cAMP-dependent protein kinase regulatory subunit; Controls the rhythmic contraction of enteric muscles probably by regulating G-protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons; Belongs to the cAMP-dependent kinase regulatory chain family. | Probable 3',5'-cyclic phosphodiesterase pde-4; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Antagonizes dorsal D (DD) motor neuron respecification by reducing levels of cAMP. | 0.914 |
kin-2 | phlp-2 | R07E4.6c.1 | F43C1.1.1 | cAMP-dependent protein kinase regulatory subunit; Controls the rhythmic contraction of enteric muscles probably by regulating G-protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons; Belongs to the cAMP-dependent kinase regulatory chain family. | Protein phosphatase PHLPP-like protein; Probable protein phosphatase. | 0.873 |
lpd-6 | phlp-2 | K09H9.6.1 | F43C1.1.1 | Brix domain-containing protein. | Protein phosphatase PHLPP-like protein; Probable protein phosphatase. | 0.700 |
pde-4 | kin-2 | R153.1d.1 | R07E4.6c.1 | Probable 3',5'-cyclic phosphodiesterase pde-4; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Antagonizes dorsal D (DD) motor neuron respecification by reducing levels of cAMP. | cAMP-dependent protein kinase regulatory subunit; Controls the rhythmic contraction of enteric muscles probably by regulating G-protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons; Belongs to the cAMP-dependent kinase regulatory chain family. | 0.914 |