node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F33D4.4 | Y37E11AM.3 | F33D4.4.1 | Y37E11AM.3b.1 | Putative sphingolipid delta(4)-desaturase; Acts as a sphingolipid delta(4)-desaturase; Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.936 |
F33D4.4 | cerk-1 | F33D4.4.1 | T10B11.2.1 | Putative sphingolipid delta(4)-desaturase; Acts as a sphingolipid delta(4)-desaturase; Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. | Ceramide kinase 1; Catalyzes the phosphorylation of ceramide to form ceramide 1- phosphate. | 0.922 |
F33D4.4 | sphk-1 | F33D4.4.1 | C34C6.5a.1 | Putative sphingolipid delta(4)-desaturase; Acts as a sphingolipid delta(4)-desaturase; Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. | Sphingosine kinase 1; Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on sphinganine (By similarity). Required for neurotransmitter release from neuromuscular junctions. Acts by recruiting the synaptic vesicle priming protein unc-13 to synapses (Probable). | 0.934 |
F33D4.4 | sptl-1 | F33D4.4.1 | C23H3.4a.2 | Putative sphingolipid delta(4)-desaturase; Acts as a sphingolipid delta(4)-desaturase; Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. | Serine palmitoyltransferase 1; Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen. | 0.520 |
F33D4.4 | sptl-2 | F33D4.4.1 | F43H9.2b.1 | Putative sphingolipid delta(4)-desaturase; Acts as a sphingolipid delta(4)-desaturase; Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. | Serine palmitoyltransferase 2; Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.893 |
F33D4.4 | sptl-3 | F33D4.4.1 | T22G5.5b.1 | Putative sphingolipid delta(4)-desaturase; Acts as a sphingolipid delta(4)-desaturase; Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. | Serine palmitoyltransferase 3; Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.564 |
F33D4.4 | ttm-5 | F33D4.4.1 | Y54E5A.1.1 | Putative sphingolipid delta(4)-desaturase; Acts as a sphingolipid delta(4)-desaturase; Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. | Putative sphingolipid delta(4)-desaturase/C4-monooxygenase; Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase. | 0.907 |
K01C8.1 | agxt-1 | K01C8.1.2 | T14D7.1.1 | ACT domain-containing protein. | Serine--pyruvate aminotransferase. | 0.936 |
K01C8.1 | mel-32 | K01C8.1.2 | C05D11.11b.2 | ACT domain-containing protein. | Serine hydroxymethyltransferase; Interconversion of serine and glycine; Belongs to the SHMT family. | 0.955 |
K01C8.1 | sptl-1 | K01C8.1.2 | C23H3.4a.2 | ACT domain-containing protein. | Serine palmitoyltransferase 1; Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen. | 0.832 |
K01C8.1 | sptl-2 | K01C8.1.2 | F43H9.2b.1 | ACT domain-containing protein. | Serine palmitoyltransferase 2; Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.837 |
K01C8.1 | sptl-3 | K01C8.1.2 | T22G5.5b.1 | ACT domain-containing protein. | Serine palmitoyltransferase 3; Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.828 |
Y37E11AM.3 | F33D4.4 | Y37E11AM.3b.1 | F33D4.4.1 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Putative sphingolipid delta(4)-desaturase; Acts as a sphingolipid delta(4)-desaturase; Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. | 0.936 |
Y37E11AM.3 | cerk-1 | Y37E11AM.3b.1 | T10B11.2.1 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Ceramide kinase 1; Catalyzes the phosphorylation of ceramide to form ceramide 1- phosphate. | 0.477 |
Y37E11AM.3 | sphk-1 | Y37E11AM.3b.1 | C34C6.5a.1 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Sphingosine kinase 1; Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on sphinganine (By similarity). Required for neurotransmitter release from neuromuscular junctions. Acts by recruiting the synaptic vesicle priming protein unc-13 to synapses (Probable). | 0.931 |
Y37E11AM.3 | sptl-1 | Y37E11AM.3b.1 | C23H3.4a.2 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Serine palmitoyltransferase 1; Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen. | 0.981 |
Y37E11AM.3 | sptl-2 | Y37E11AM.3b.1 | F43H9.2b.1 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Serine palmitoyltransferase 2; Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.958 |
Y37E11AM.3 | sptl-3 | Y37E11AM.3b.1 | T22G5.5b.1 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Serine palmitoyltransferase 3; Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.957 |
Y37E11AM.3 | ttm-5 | Y37E11AM.3b.1 | Y54E5A.1.1 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Putative sphingolipid delta(4)-desaturase/C4-monooxygenase; Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase. | 0.936 |
agxt-1 | K01C8.1 | T14D7.1.1 | K01C8.1.2 | Serine--pyruvate aminotransferase. | ACT domain-containing protein. | 0.936 |