node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F19B10.6 | F49E11.7 | F19B10.6.1 | F49E11.7.1 | Uncharacterized protein. | Serine/threonine-protein phosphatase. | 0.852 |
F19B10.6 | Y54E10BR.3 | F19B10.6.1 | Y54E10BR.3.1 | Uncharacterized protein. | RING-type domain-containing protein. | 0.850 |
F19B10.6 | lin-36 | F19B10.6.1 | F44B9.6.1 | Uncharacterized protein. | Protein lin-36; Required to negatively regulate vulval development. Antagonizes Ras-mediated vulval induction. Acts cell autonomously. | 0.590 |
F49E11.7 | F19B10.6 | F49E11.7.1 | F19B10.6.1 | Serine/threonine-protein phosphatase. | Uncharacterized protein. | 0.852 |
F49E11.7 | Y54E10BR.3 | F49E11.7.1 | Y54E10BR.3.1 | Serine/threonine-protein phosphatase. | RING-type domain-containing protein. | 0.852 |
F49E11.7 | lin-35 | F49E11.7.1 | C32F10.2.1 | Serine/threonine-protein phosphatase. | Retinoblastoma-like protein homolog lin-35; Key regulator of cell division which acts as a transcriptional repressor and negatively regulates cell cycle progression in its active unphosphorylated form, but allows cell cycle progression when phosphorylated. When unphosphorylated and in its active form, interacts with E2F transcription factors such as efl-1 to repress their transcriptional activity and negatively regulate the progression through the G1 phase of the cell cycle during postembryonic development. May furthermore act with cell cycle regulator cki-1 to negatively regulate cell [...] | 0.408 |
F49E11.7 | lin-36 | F49E11.7.1 | F44B9.6.1 | Serine/threonine-protein phosphatase. | Protein lin-36; Required to negatively regulate vulval development. Antagonizes Ras-mediated vulval induction. Acts cell autonomously. | 0.590 |
Y54E10BR.3 | F19B10.6 | Y54E10BR.3.1 | F19B10.6.1 | RING-type domain-containing protein. | Uncharacterized protein. | 0.850 |
Y54E10BR.3 | F49E11.7 | Y54E10BR.3.1 | F49E11.7.1 | RING-type domain-containing protein. | Serine/threonine-protein phosphatase. | 0.852 |
Y54E10BR.3 | lin-36 | Y54E10BR.3.1 | F44B9.6.1 | RING-type domain-containing protein. | Protein lin-36; Required to negatively regulate vulval development. Antagonizes Ras-mediated vulval induction. Acts cell autonomously. | 0.594 |
dpl-1 | lin-15A | T23G7.1.1 | ZK678.1.2 | Transcription factor dpl-1; Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription. May also negatively regulate vulval development in association with other SynMuv class B proteins such as lin-15A. Can stimulate E2F-dependent transcription. Plays a role in negatively regulating the progression through the G1 phase of the cell cycle during postembryonic development, most likely by acting as a transcriptional repress [...] | Protein lin-15A; Synthetic multivulva (synMuv) class A protein. SynMuv proteins are required to repress the induction of vulval development. Acts redundantly with SynMuv class B protein lin-15B, and lin-35 to negatively regulate vulval development, most likely through antagonization of the Ras-signaling pathway. May also negatively regulate vulval development in association with other SynMuv class B proteins such as dpl-1 and efl-1. Regulates let-23 basal activity. Required for the correct expression and/or stability of lin-56. | 0.598 |
dpl-1 | lin-15B | T23G7.1.1 | ZK662.4.2 | Transcription factor dpl-1; Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription. May also negatively regulate vulval development in association with other SynMuv class B proteins such as lin-15A. Can stimulate E2F-dependent transcription. Plays a role in negatively regulating the progression through the G1 phase of the cell cycle during postembryonic development, most likely by acting as a transcriptional repress [...] | Protein lin-15B; Synthetic multivulva (synMuv) class B protein. SynMuv proteins are required to repress the induction of vulval development. Acts redundantly with SynMuv class A protein lin-15A to negatively regulate vulval development. Regulates let-23 basal activity. | 0.682 |
dpl-1 | lin-35 | T23G7.1.1 | C32F10.2.1 | Transcription factor dpl-1; Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription. May also negatively regulate vulval development in association with other SynMuv class B proteins such as lin-15A. Can stimulate E2F-dependent transcription. Plays a role in negatively regulating the progression through the G1 phase of the cell cycle during postembryonic development, most likely by acting as a transcriptional repress [...] | Retinoblastoma-like protein homolog lin-35; Key regulator of cell division which acts as a transcriptional repressor and negatively regulates cell cycle progression in its active unphosphorylated form, but allows cell cycle progression when phosphorylated. When unphosphorylated and in its active form, interacts with E2F transcription factors such as efl-1 to repress their transcriptional activity and negatively regulate the progression through the G1 phase of the cell cycle during postembryonic development. May furthermore act with cell cycle regulator cki-1 to negatively regulate cell [...] | 0.999 |
dpl-1 | lin-36 | T23G7.1.1 | F44B9.6.1 | Transcription factor dpl-1; Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription. May also negatively regulate vulval development in association with other SynMuv class B proteins such as lin-15A. Can stimulate E2F-dependent transcription. Plays a role in negatively regulating the progression through the G1 phase of the cell cycle during postembryonic development, most likely by acting as a transcriptional repress [...] | Protein lin-36; Required to negatively regulate vulval development. Antagonizes Ras-mediated vulval induction. Acts cell autonomously. | 0.737 |
dpl-1 | lin-37 | T23G7.1.1 | ZK418.4.1 | Transcription factor dpl-1; Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription. May also negatively regulate vulval development in association with other SynMuv class B proteins such as lin-15A. Can stimulate E2F-dependent transcription. Plays a role in negatively regulating the progression through the G1 phase of the cell cycle during postembryonic development, most likely by acting as a transcriptional repress [...] | Uncharacterized protein. | 0.983 |
dpl-1 | lin-9 | T23G7.1.1 | ZK637.7b.1 | Transcription factor dpl-1; Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription. May also negatively regulate vulval development in association with other SynMuv class B proteins such as lin-15A. Can stimulate E2F-dependent transcription. Plays a role in negatively regulating the progression through the G1 phase of the cell cycle during postembryonic development, most likely by acting as a transcriptional repress [...] | Protein lin-9; Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription. Required for the development of sheath cells in the hermaphrodite gonad and for the development of the male spicule, rays and gonad. In association with the zinc finger protein ztf-11, negatively regulates the expression of non- neuronal genes during neurogenesis. | 0.971 |
lin-15A | dpl-1 | ZK678.1.2 | T23G7.1.1 | Protein lin-15A; Synthetic multivulva (synMuv) class A protein. SynMuv proteins are required to repress the induction of vulval development. Acts redundantly with SynMuv class B protein lin-15B, and lin-35 to negatively regulate vulval development, most likely through antagonization of the Ras-signaling pathway. May also negatively regulate vulval development in association with other SynMuv class B proteins such as dpl-1 and efl-1. Regulates let-23 basal activity. Required for the correct expression and/or stability of lin-56. | Transcription factor dpl-1; Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription. May also negatively regulate vulval development in association with other SynMuv class B proteins such as lin-15A. Can stimulate E2F-dependent transcription. Plays a role in negatively regulating the progression through the G1 phase of the cell cycle during postembryonic development, most likely by acting as a transcriptional repress [...] | 0.598 |
lin-15A | lin-15B | ZK678.1.2 | ZK662.4.2 | Protein lin-15A; Synthetic multivulva (synMuv) class A protein. SynMuv proteins are required to repress the induction of vulval development. Acts redundantly with SynMuv class B protein lin-15B, and lin-35 to negatively regulate vulval development, most likely through antagonization of the Ras-signaling pathway. May also negatively regulate vulval development in association with other SynMuv class B proteins such as dpl-1 and efl-1. Regulates let-23 basal activity. Required for the correct expression and/or stability of lin-56. | Protein lin-15B; Synthetic multivulva (synMuv) class B protein. SynMuv proteins are required to repress the induction of vulval development. Acts redundantly with SynMuv class A protein lin-15A to negatively regulate vulval development. Regulates let-23 basal activity. | 0.897 |
lin-15A | lin-35 | ZK678.1.2 | C32F10.2.1 | Protein lin-15A; Synthetic multivulva (synMuv) class A protein. SynMuv proteins are required to repress the induction of vulval development. Acts redundantly with SynMuv class B protein lin-15B, and lin-35 to negatively regulate vulval development, most likely through antagonization of the Ras-signaling pathway. May also negatively regulate vulval development in association with other SynMuv class B proteins such as dpl-1 and efl-1. Regulates let-23 basal activity. Required for the correct expression and/or stability of lin-56. | Retinoblastoma-like protein homolog lin-35; Key regulator of cell division which acts as a transcriptional repressor and negatively regulates cell cycle progression in its active unphosphorylated form, but allows cell cycle progression when phosphorylated. When unphosphorylated and in its active form, interacts with E2F transcription factors such as efl-1 to repress their transcriptional activity and negatively regulate the progression through the G1 phase of the cell cycle during postembryonic development. May furthermore act with cell cycle regulator cki-1 to negatively regulate cell [...] | 0.704 |
lin-15A | lin-36 | ZK678.1.2 | F44B9.6.1 | Protein lin-15A; Synthetic multivulva (synMuv) class A protein. SynMuv proteins are required to repress the induction of vulval development. Acts redundantly with SynMuv class B protein lin-15B, and lin-35 to negatively regulate vulval development, most likely through antagonization of the Ras-signaling pathway. May also negatively regulate vulval development in association with other SynMuv class B proteins such as dpl-1 and efl-1. Regulates let-23 basal activity. Required for the correct expression and/or stability of lin-56. | Protein lin-36; Required to negatively regulate vulval development. Antagonizes Ras-mediated vulval induction. Acts cell autonomously. | 0.765 |