STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sra-11Serpentine receptor class alpha-11; A G protein-coupled receptor required for olfactory imprinting a requisite in ordorant response such as benzaldehyde and isoamylalcohol; Belongs to the nematode receptor-like protein sra family. (334 aa)    
Predicted Functional Partners:
ttx-3
LIM/homeobox protein ttx-3; Required for specification of the AIA and AIY interneurons and the NSM neurons. Positively regulates the expression of a number of genes including ceh-23, kal-1, hen-1, ser-2, unc-17 and sra-11 in AIY interneurons and cat-4, flp-4, bas-1, ptps-1 and mgl-1 in NSM neurons. Also acts in an autoregulatory feedback loop to maintain its own expression. Plays a role in the thermotactic response, olfactory imprinting, regulation of longevity, control of dauer formation and axon outgrowth and pathfinding. Not required for normal chemosensory behavior.
      
 0.850
ceh-10
Homeobox protein ceh-10; Required for larval development and for cell fate specification and migration of CAN neurons.
      
 0.807
ceh-23
Homeobox protein ceh-23.
      
 0.741
ser-2
Tyramine receptor Ser-2; G-protein coupled receptor for tyramine, a known neurotransmitter and neuromodulator and direct precursor of octopamine. The rank order of potency is tyramine > octopamine > dopamine > serotonin > epinephrine = norepinephrine.
      
 0.691
nmr-1
NMDA-type ionotropic glutamate receptor NMR-1; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
      
 0.691
nlf-1
NCA Localization Factor.
      
 0.660
kal-1
KALlmann syndrome homolog.
      
 0.628
acbp-6
ACB domain-containing protein.
      
 0.616
cex-1
Calexcitin-1.
      
 0.584
ceh-24
Homeobox protein ceh-24; Probable transcriptional regulator that is required in neural development for the normal formation of sublateral cholinergic motor neuron processes. Plays a role in regulating the expression of acetylcholine transporter protein unc-17 in the sublateral processes. In particular, it is required in sublateral motor neurons for a left- right turning behavior that occurs during the lethargus phase of the normal sleep process called 'flipping'. During 'flipping' animals rotate 180 degrees about their longitudinal axis.
   
  
 0.556
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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