STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rgs-10Regulator of G-protein signaling rgs-10; Shown to have a role in viability and embryogenesis. (270 aa)    
Predicted Functional Partners:
rgs-6
Regulator of G-protein signaling rgs-6.
   
 
 0.884
rgs-3
Regulator of G-protein signaling rgs-3; Modulates chemotaxis responses by regulating positively the sensitivity to CO2 levels in BAG neurons and by regulating negatively the sensitivity to quinine in ASH sensory neurons.
     
 0.879
rgs-4
RGS domain-containing protein.
   
  
 0.811
gpb-1
Guanine nucleotide-binding protein subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. In the early embryo, controls the magnitude of the forces acting on centrosomes but is not required for generating asymmetric forces.
   
 0.719
gpb-2
Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
   
 0.719
egl-10
Regulator of G-protein signaling egl-10; Involved in egg-laying and locomotion. May regulate G protein goa-1 signaling.
     
 0.714
gcy-17
Receptor-type guanylate cyclase gcy-17; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
      
 0.707
gcy-25
Receptor-type guanylate cyclase gcy-25; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
      
 0.701
gcy-20
Receptor-type guanylate cyclase gcy-20; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).
      
 0.670
gcy-15
Receptor-type guanylate cyclase gcy-15; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).
      
 0.670
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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