node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F47D12.9 | R11D1.1 | F47D12.9a.4 | R11D1.1b.1 | Uncharacterized WD repeat-containing protein F47D12.9. | Uncharacterized protein. | 0.844 |
F47D12.9 | W02B12.12 | F47D12.9a.4 | W02B12.12a.1 | Uncharacterized WD repeat-containing protein F47D12.9. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.916 |
F47D12.9 | adpr-1 | F47D12.9a.4 | Y73E7A.9a.1 | Uncharacterized WD repeat-containing protein F47D12.9. | WD_REPEATS_REGION domain-containing protein. | 0.640 |
F47D12.9 | csn-6 | F47D12.9a.4 | Y67H2A.6b.1 | Uncharacterized WD repeat-containing protein F47D12.9. | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mi [...] | 0.608 |
F47D12.9 | cul-4 | F47D12.9a.4 | F45E12.3.1 | Uncharacterized WD repeat-containing protein F47D12.9. | Cullin-4; Component of cullin-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. In association with ddb-1 directs ubiquitination of cdt-1 during S phase and is required for restraining DNA rereplication. Probably is involved in ubiquitination of cki-1. | 0.766 |
F47D12.9 | dcaf-1 | F47D12.9a.4 | ZK1251.9a.1 | Uncharacterized WD repeat-containing protein F47D12.9. | DDB1- and CUL4-associated factor homolog 1; Component of the cul4-rbx1-ddb1-dcaf1 E3 ubiquitin-protein ligase complex, dcaf1 may function as the substrate recognition module within this complex. | 0.638 |
F47D12.9 | ddb-1 | F47D12.9a.4 | M18.5.1 | Uncharacterized WD repeat-containing protein F47D12.9. | DNA damage-binding protein 1; Plays a role in DNA repair. May be a component of an E3 ubiquitin-protein ligase which promotes histone ubiquitination in response to UV irradiation. Histone ubiquitination may be important for subsequent DNA repair (By similarity). Promotes the degradation of the replication licensing factor cdt-1 during S-phase, thereby preventing rereplication of DNA during a single round of cell division. | 0.967 |
F47D12.9 | gcy-21 | F47D12.9a.4 | F22E5.3.1 | Uncharacterized WD repeat-containing protein F47D12.9. | Receptor-type guanylate cyclase gcy-21; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). | 0.904 |
F47D12.9 | rbx-1 | F47D12.9a.4 | ZK287.5.2 | Uncharacterized WD repeat-containing protein F47D12.9. | RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation. | 0.590 |
F47D12.9 | wdr-23 | F47D12.9a.4 | D2030.9a.2 | Uncharacterized WD repeat-containing protein F47D12.9. | DDB1- and CUL4-associated factor 11 homolog; Involved in regulation of lifespan. Required for dopaminergic CEP neuron degeneration in response to Mn(2+). | 0.715 |
R11D1.1 | F47D12.9 | R11D1.1b.1 | F47D12.9a.4 | Uncharacterized protein. | Uncharacterized WD repeat-containing protein F47D12.9. | 0.844 |
R11D1.1 | adpr-1 | R11D1.1b.1 | Y73E7A.9a.1 | Uncharacterized protein. | WD_REPEATS_REGION domain-containing protein. | 0.551 |
R11D1.1 | csn-6 | R11D1.1b.1 | Y67H2A.6b.1 | Uncharacterized protein. | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mi [...] | 0.435 |
R11D1.1 | cul-4 | R11D1.1b.1 | F45E12.3.1 | Uncharacterized protein. | Cullin-4; Component of cullin-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. In association with ddb-1 directs ubiquitination of cdt-1 during S phase and is required for restraining DNA rereplication. Probably is involved in ubiquitination of cki-1. | 0.696 |
R11D1.1 | dcaf-1 | R11D1.1b.1 | ZK1251.9a.1 | Uncharacterized protein. | DDB1- and CUL4-associated factor homolog 1; Component of the cul4-rbx1-ddb1-dcaf1 E3 ubiquitin-protein ligase complex, dcaf1 may function as the substrate recognition module within this complex. | 0.585 |
R11D1.1 | ddb-1 | R11D1.1b.1 | M18.5.1 | Uncharacterized protein. | DNA damage-binding protein 1; Plays a role in DNA repair. May be a component of an E3 ubiquitin-protein ligase which promotes histone ubiquitination in response to UV irradiation. Histone ubiquitination may be important for subsequent DNA repair (By similarity). Promotes the degradation of the replication licensing factor cdt-1 during S-phase, thereby preventing rereplication of DNA during a single round of cell division. | 0.960 |
R11D1.1 | rbx-1 | R11D1.1b.1 | ZK287.5.2 | Uncharacterized protein. | RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation. | 0.549 |
R11D1.1 | wdr-23 | R11D1.1b.1 | D2030.9a.2 | Uncharacterized protein. | DDB1- and CUL4-associated factor 11 homolog; Involved in regulation of lifespan. Required for dopaminergic CEP neuron degeneration in response to Mn(2+). | 0.643 |
W02B12.12 | F47D12.9 | W02B12.12a.1 | F47D12.9a.4 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Uncharacterized WD repeat-containing protein F47D12.9. | 0.916 |
W02B12.12 | gcy-21 | W02B12.12a.1 | F22E5.3.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Receptor-type guanylate cyclase gcy-21; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). | 0.748 |