STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
amt-2Putative ammonium transporter 2; Involved in the uptake of ammonia (Probable). Implicated in aging; Belongs to the ammonia transporter channel (TC 1.A.11.2) family. (515 aa)    
Predicted Functional Partners:
damt-1
DNA N6-methyl methyltransferase; Methylates DNA on the 6th position of adenine (N(6)- methyladenosine). N(6)-methyladenosine (m6A) DNA is involved in epigenetic transgenerational inheritance. Belongs to the MT-A70-like family.
      
 0.812
sor-3
Sop-2-related protein 3; Probably acts synergistically with sop-2 to maintain the transcriptionally repressive state of homeotic genes in order to regulate various neurogenic identities. Specification of some neuronal identities also involves expression of non-Hox genes. Specifies dopaminergic and serotonergic neuronal cell fate, and regulates neurotransmitter choice and axon pathfinding.
      
 0.699
smcl-1
Structural maintenance of chromosomes-like protein 1; Acts as a modulator of condensin function, possibly by binding to the condensin SMC subunits and thereby inhibiting their function. Negatively regulates the condensin I complex in mitotic chromosome segregation. Negatively regulates the condensin I-like dosage compensation complex, which functions in the regulation of X chromosome-linked gene transcription, by limiting the association of the complex with the X chromosomes.
     
 0.685
alh-13
Probable delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
     
 0.585
W07E11.1
Glutamine amidotransferase type-2 domain-containing protein.
 
   
 0.529
aco-2
Probable aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
  
 0.520
aco-1
Probable cytoplasmic aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
  
 0.520
cts-1
Probable citrate synthase, mitochondrial.
  
  
 0.440
rpia-1
Probable-ribose 5-phosphate isomerase; Belongs to the ribose 5-phosphate isomerase family.
     
 0.436
Y52B11A.3
Uncharacterized protein.
   
  
 0.425
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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