STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dif-1Protein dif-1; Seems to play a role in the maintenance of tissue differentiation in the developing embryo, but not for its initiation. (312 aa)    
Predicted Functional Partners:
cpt-2
Calponin-homology (CH) domain-containing protein.
   
  
 0.956
ipla-6
PNPLA domain-containing protein.
 
      0.878
zgpa-1
Zinc finger G-PAtch domain-containing protein homolog.
 
    
 0.877
B0395.3
Carn_acyltransf domain-containing protein; Belongs to the carnitine/choline acetyltransferase family.
   
 
 0.758
cha-1
Choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses (By similarity). Required in SIA sublateral cholinergic motor neurons for a left-right turning behavior that occurs during the lethargus phase of the normal sleep process called 'flipping'. During 'flipping' animals rotate 180 degrees about their longitudinal axis ; Belongs to the carnitine/choline acetyltransferase family.
   
 
 0.750
acdh-12
Acyl CoA DeHydrogenase.
   
  
 0.741
acdh-7
Acyl CoA DeHydrogenase.
   
  
 0.732
maoc-1
MAO-C-like dehydratase domain.
   
  
 0.730
ech-6
Probable enoyl-CoA hydratase, mitochondrial.
   
  
 0.729
aph-1
Gamma-secretase subunit aph-1; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors (lin-12 or glp-1). It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Required for the localization of aph-2.
      
 0.703
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.