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ifa-3 protein (Caenorhabditis elegans) - STRING interaction network
"ifa-3" - Intermediate filament protein ifa-3 in Caenorhabditis elegans
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
ifa-3Intermediate filament protein ifa-3; Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Required for epidermal morphogenesis in embryos. Probable component of embryonic epidermal attachment structures (581 aa)    
Predicted Functional Partners:
ifd-1
Intermediate filament protein ifd-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein (575 aa)
         
0.923
ifc-1
Intermediate filament protein ifc-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein (500 aa)
         
0.921
ifd-2
Intermediate filament protein ifd-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein (443 aa)
     
 
0.920
ifc-2
Intermediate filament protein ifc-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein, although its absence leads to mild defects in locomotion (1248 aa)
         
0.918
ifb-2
Intermediate filament protein ifb-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. Component of the terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) in embryonic through to adult gut cells. Correct localization of filaments requires let-413 (577 aa)
         
0.913
lev-11
Tropomyosin isoforms a/b/d/f; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. Involved in muscle actin filament organization and muscle arm extension and morphology. Also has a role in male mating behavior by regulating the copulatory spicules. Binds to F- actin (284 aa)
     
 
  0.912
dys-1
Dystrophin-1; Plays a role in cholinergic transmission and as a functional partner of dystrobrevin (dyb-1), necessary for muscle maintenance. Required for neuronal positioning (3674 aa)
     
  0.912
dlg-1
Drosophila Discs LarGe homolog; Protein DLG-1, isoform a; Belongs to the MAGUK family (967 aa)
     
 
  0.912
F42H10.3
LIM and SH3 domain protein F42H10.3; Protein F42H10.3, isoform a (F42H10.3) mRNA, complete cds (335 aa)
     
  0.909
ifb-1
Intermediate filament protein ifb-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Required in morphogenesis and epidermal integrity. Probable component of embryonic epidermal attachment structures. Functions in larval muscle attachment independently of ifa-2 (589 aa)
     
 
0.908
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Caenorhabditis elegans, Rhabditis elegans, roundworm
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