node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C23G10.11 | C54F6.5 | C23G10.11.1 | C54F6.5.1 | Uncharacterized protein. | Uncharacterized protein. | 0.705 |
C23G10.11 | F41C3.1 | C23G10.11.1 | F41C3.1.1 | Uncharacterized protein. | Uncharacterized protein. | 0.706 |
C23G10.11 | swan-1 | C23G10.11.1 | F53C11.8.2 | Uncharacterized protein. | WD_REPEATS_REGION domain-containing protein. | 0.660 |
C54F6.5 | C23G10.11 | C54F6.5.1 | C23G10.11.1 | Uncharacterized protein. | Uncharacterized protein. | 0.705 |
C54F6.5 | F41C3.1 | C54F6.5.1 | F41C3.1.1 | Uncharacterized protein. | Uncharacterized protein. | 0.851 |
C54F6.5 | swan-1 | C54F6.5.1 | F53C11.8.2 | Uncharacterized protein. | WD_REPEATS_REGION domain-containing protein. | 0.660 |
F41C3.1 | C23G10.11 | F41C3.1.1 | C23G10.11.1 | Uncharacterized protein. | Uncharacterized protein. | 0.706 |
F41C3.1 | C54F6.5 | F41C3.1.1 | C54F6.5.1 | Uncharacterized protein. | Uncharacterized protein. | 0.851 |
F41C3.1 | swan-1 | F41C3.1.1 | F53C11.8.2 | Uncharacterized protein. | WD_REPEATS_REGION domain-containing protein. | 0.660 |
cysl-1 | egl-9 | C17G1.7.1 | F22E12.4a.2 | Cysteine synthase 1; Catalyzes the formation of cysteine and acetate from O- acetylserine and hydrogen sulfide. By metabolizing hydrogen sulfide produced by cysl-2-mediated cyanide assimilation, mediates resistance to P.aeruginosa infection. Mediates survival in high levels of hydrogen sulfide. By sequestering egl-9, which in turn promotes hif-1- mediated transcription, regulates behavioral responses to hypoxia ; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Hypoxia-inducible factor prolyl hydroxylase; Cellular oxygen sensor which regulates the stability and the activity of hypoxia-inducible transcription factor, hif-1. In normoxic conditions, hydroxylates hif-1 targeting it for vhl-1-mediated proteasomal degradation. In addition, regulates hif-1 transcriptional activity in a vhl-1-independent manner and independently of its hydroxylase activity. By regulating hif-1 activity, controls several cellular responses. Mediates susceptibility to B.thuringiensis and V.cholerae pore-forming toxins and enteropathogenic E.coli. Mediates susceptibilit [...] | 0.964 |
cysl-1 | mbk-1 | C17G1.7.1 | T04C10.1.1 | Cysteine synthase 1; Catalyzes the formation of cysteine and acetate from O- acetylserine and hydrogen sulfide. By metabolizing hydrogen sulfide produced by cysl-2-mediated cyanide assimilation, mediates resistance to P.aeruginosa infection. Mediates survival in high levels of hydrogen sulfide. By sequestering egl-9, which in turn promotes hif-1- mediated transcription, regulates behavioral responses to hypoxia ; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1; Possible role in the function of olfactory neurons. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. | 0.542 |
cysl-1 | rhy-1 | C17G1.7.1 | W07A12.7.1 | Cysteine synthase 1; Catalyzes the formation of cysteine and acetate from O- acetylserine and hydrogen sulfide. By metabolizing hydrogen sulfide produced by cysl-2-mediated cyanide assimilation, mediates resistance to P.aeruginosa infection. Mediates survival in high levels of hydrogen sulfide. By sequestering egl-9, which in turn promotes hif-1- mediated transcription, regulates behavioral responses to hypoxia ; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Regulator of hypoxia-inducible factor 1; Involved in the response to variation in environmental oxygen levels by inhibiting hif-1-mediated gene transcription in a vhl-1- independent manner. Plays a role in susceptibility to killing mediated by P.aeruginosa and by pore-forming toxins produced by B.thuringiensis. Probably by preventing hif-1 transcriptional activity, regulates behavioral responses, such as locomotion speed following acute reoxygenation. Plays a role in normal egg-laying probably by regulating spermatogenesis and in body morphogenesis. | 0.852 |
cysl-1 | swan-1 | C17G1.7.1 | F53C11.8.2 | Cysteine synthase 1; Catalyzes the formation of cysteine and acetate from O- acetylserine and hydrogen sulfide. By metabolizing hydrogen sulfide produced by cysl-2-mediated cyanide assimilation, mediates resistance to P.aeruginosa infection. Mediates survival in high levels of hydrogen sulfide. By sequestering egl-9, which in turn promotes hif-1- mediated transcription, regulates behavioral responses to hypoxia ; Belongs to the cysteine synthase/cystathionine beta- synthase family. | WD_REPEATS_REGION domain-containing protein. | 0.660 |
egl-9 | cysl-1 | F22E12.4a.2 | C17G1.7.1 | Hypoxia-inducible factor prolyl hydroxylase; Cellular oxygen sensor which regulates the stability and the activity of hypoxia-inducible transcription factor, hif-1. In normoxic conditions, hydroxylates hif-1 targeting it for vhl-1-mediated proteasomal degradation. In addition, regulates hif-1 transcriptional activity in a vhl-1-independent manner and independently of its hydroxylase activity. By regulating hif-1 activity, controls several cellular responses. Mediates susceptibility to B.thuringiensis and V.cholerae pore-forming toxins and enteropathogenic E.coli. Mediates susceptibilit [...] | Cysteine synthase 1; Catalyzes the formation of cysteine and acetate from O- acetylserine and hydrogen sulfide. By metabolizing hydrogen sulfide produced by cysl-2-mediated cyanide assimilation, mediates resistance to P.aeruginosa infection. Mediates survival in high levels of hydrogen sulfide. By sequestering egl-9, which in turn promotes hif-1- mediated transcription, regulates behavioral responses to hypoxia ; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.964 |
egl-9 | rhy-1 | F22E12.4a.2 | W07A12.7.1 | Hypoxia-inducible factor prolyl hydroxylase; Cellular oxygen sensor which regulates the stability and the activity of hypoxia-inducible transcription factor, hif-1. In normoxic conditions, hydroxylates hif-1 targeting it for vhl-1-mediated proteasomal degradation. In addition, regulates hif-1 transcriptional activity in a vhl-1-independent manner and independently of its hydroxylase activity. By regulating hif-1 activity, controls several cellular responses. Mediates susceptibility to B.thuringiensis and V.cholerae pore-forming toxins and enteropathogenic E.coli. Mediates susceptibilit [...] | Regulator of hypoxia-inducible factor 1; Involved in the response to variation in environmental oxygen levels by inhibiting hif-1-mediated gene transcription in a vhl-1- independent manner. Plays a role in susceptibility to killing mediated by P.aeruginosa and by pore-forming toxins produced by B.thuringiensis. Probably by preventing hif-1 transcriptional activity, regulates behavioral responses, such as locomotion speed following acute reoxygenation. Plays a role in normal egg-laying probably by regulating spermatogenesis and in body morphogenesis. | 0.855 |
egl-9 | swan-1 | F22E12.4a.2 | F53C11.8.2 | Hypoxia-inducible factor prolyl hydroxylase; Cellular oxygen sensor which regulates the stability and the activity of hypoxia-inducible transcription factor, hif-1. In normoxic conditions, hydroxylates hif-1 targeting it for vhl-1-mediated proteasomal degradation. In addition, regulates hif-1 transcriptional activity in a vhl-1-independent manner and independently of its hydroxylase activity. By regulating hif-1 activity, controls several cellular responses. Mediates susceptibility to B.thuringiensis and V.cholerae pore-forming toxins and enteropathogenic E.coli. Mediates susceptibilit [...] | WD_REPEATS_REGION domain-containing protein. | 0.774 |
gtbp-1 | swan-1 | K08F4.2.1 | F53C11.8.2 | Ras-Gtpase-activating protein SH3 (Three) domain-Binding Protein. | WD_REPEATS_REGION domain-containing protein. | 0.660 |
hpk-1 | swan-1 | F20B6.8b.1 | F53C11.8.2 | Homeodomain-interacting protein kinase 1; Serine/threonine-protein kinase required in the somatic gonadal cells to regulate germline proliferation during larval development and in adulthood. Plays a role in the development/differentiation of gonadal distal tip cells. Required for normal lifespan in a pha-4 and mxl-2- dependent manner. Also contributes to survival following heat or oxidative stress. Prevents sumoylation and inactivation of heat shock transcription factor hsf-1 which enhances hsf-1-dependent transcriptional induction of chaperones in response to heat shock. Also required [...] | WD_REPEATS_REGION domain-containing protein. | 0.648 |
mbk-1 | cysl-1 | T04C10.1.1 | C17G1.7.1 | Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1; Possible role in the function of olfactory neurons. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. | Cysteine synthase 1; Catalyzes the formation of cysteine and acetate from O- acetylserine and hydrogen sulfide. By metabolizing hydrogen sulfide produced by cysl-2-mediated cyanide assimilation, mediates resistance to P.aeruginosa infection. Mediates survival in high levels of hydrogen sulfide. By sequestering egl-9, which in turn promotes hif-1- mediated transcription, regulates behavioral responses to hypoxia ; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.542 |
mbk-1 | swan-1 | T04C10.1.1 | F53C11.8.2 | Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1; Possible role in the function of olfactory neurons. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. | WD_REPEATS_REGION domain-containing protein. | 0.946 |