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ina-1 protein (Caenorhabditis elegans) - STRING interaction network
"ina-1" - Integrin alpha ina-1 in Caenorhabditis elegans
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ina-1Integrin alpha ina-1 ; Plays a role in cell migration, axon fasciculation, and morphogenesis (PubMed-9247263). During gonad morphogenesis, involved in distal tip cells (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration (PubMed-19023419). Involved in the anterior- posterior positioning of QR neuroblast descendants by regulating the migratory speed of QR.p (PubMed-25373777). Probably by acting as a receptor for apoptotic cells, plays a role in the clearance of apoptotic cells during mid-embryogenesis (PubMed-20226672) (1139 aa)    
Predicted Functional Partners:
pat-3
Integrin beta pat-3 ; Possible role in cell-cell interactions. Integrin alpha pat-1/beta pat-3 is a receptor for laminin. Integrin alpha pat- 2/beta pat-3 recognizes the sequence R-G-D in its ligands (By similarity). During gonad morphogenesis, involved in distal tip cell (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration (PubMed-19023419). Plays a role in the clearance of apoptotic cells during mid-embryogenesis (PubMed-20226672) (809 aa)
     
  0.995
let-2
Collagen alpha-2(IV) chain ; Collagen type IV is specific for basement membranes. Vital for embryonic development (1759 aa)
       
  0.955
lam-2
Laminin-like protein lam-2 ; During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3 (1633 aa)
         
  0.954
lam-1
LAMinin related. See also lmb- family member (lam-1) (1067 aa)
     
 
  0.953
cle-1
CoLlagen with Endostatin domain family member (cle-1) (1175 aa)
         
  0.953
emb-9
Collagen alpha-1(IV) chain ; Collagen type IV is specific for basement membranes (1759 aa)
       
  0.953
vab-10
Variable ABnormal morphology family member (vab-10) (4955 aa)
       
  0.936
lam-3
LAMinin related. See also lmb- family member (lam-3) (3102 aa)
         
  0.921
W03F8.10
Protein W03F8.10 (587 aa)
     
 
    0.904
F01F1.13
Protein F01F1.13 ; Required for determination of left/right asymmetry in nervous system. Acts together with unc-40 to control an initial left-right asymmetric polarization of the Q neuroblasts. Mig-21 and unc-40 may control the asymmetry in Wnt signaling response by restricting posterior polarization to one of the 2 Q neuroblasts. Involved in left-side QL posterior migration. In right-side QR, unc-40 and mig-21 pathways mutually inhibit each other in posterior migration, allowing anterior QR migration (192 aa)
         
    0.900
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Caenorhabditis elegans, Rhabditis elegans, nematode
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