STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rad-8Reticulon-4-interacting protein 1, mitochondrial; Plays a role in oxygen metabolism in the mitochondria by regulating the levels of reactive oxygen species (ROS) thereby conferring resistance to oxidative stress. Involved in resistance to P.aeruginosa PA14 infection. Regulates lifespan. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. (366 aa)    
Predicted Functional Partners:
pks-1
PolyKetide Synthase.
  
 0.859
oxy-4
Probable cytosolic Fe-S cluster assembly factor oxy-4; Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins (By similarity); Belongs to the NARF family.
      
 0.812
icl-1
Bifunctional glyoxylate cycle protein; In the C-terminal section; belongs to the malate synthase family.
  
  
 0.772
mev-1
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity). Mediates resistance to enteropathogenic E.coli infection. Belongs to the cytochrome b560 family.
  
 
 0.753
F33E11.3
KLRAQ domain-containing protein.
    
   0.749
mecr-1
Enoyl-[acyl-carrier-protein] reductase, mitochondrial; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
  
  
 0.658
R08D7.7
Uncharacterized sugar kinase R08D7.7; Belongs to the FGGY kinase family.
     
 0.654
dhs-6
SCP2 domain-containing protein.
  
 0.635
fasn-1
Carrier domain-containing protein.
  
0.628
F32H2.6
Ketoacyl_synth_N domain-containing protein.
  
 0.628
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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