STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ldb-1LID domain-containing protein. (629 aa)    
Predicted Functional Partners:
sam-10
Single-stranded DNA-binding protein homolog sam-10; Involved cell autonomously in PLM neuron pre-synaptic differentiation by negatively regulating prk-2 expression and in neurite branch positioning.
   
 
 0.980
ttx-3
LIM/homeobox protein ttx-3; Required for specification of the AIA and AIY interneurons and the NSM neurons. Positively regulates the expression of a number of genes including ceh-23, kal-1, hen-1, ser-2, unc-17 and sra-11 in AIY interneurons and cat-4, flp-4, bas-1, ptps-1 and mgl-1 in NSM neurons. Also acts in an autoregulatory feedback loop to maintain its own expression. Plays a role in the thermotactic response, olfactory imprinting, regulation of longevity, control of dauer formation and axon outgrowth and pathfinding. Not required for normal chemosensory behavior.
   
 
 0.914
lim-7
LIM domain family.
   
 
 0.902
ceh-14
Homeobox protein ceh-14; Confers thermosensory function to neurons. Required for correct AFD-mediated thermotaxis.
    
 
 0.842
T09D3.8
DUF281 domain-containing protein.
      
 0.806
D2007.2
Uncharacterized protein D2007.2.
      
 0.801
pxd-1
PleXin Domain containing.
   
  
 0.778
pitp-1
DDHD domain-containing protein.
   
  
 0.763
dmsr-2
G_PROTEIN_RECEP_F1_2 domain-containing protein.
    
 
 0.760
drn-1
GTP-binding protein drn-1; Displays low GTPase activity and exists predominantly in the GTP-bound form (By similarity). Together with epac-1, may regulate acetylcholine release at the neuromuscular junctions probably downstream of G-protein gsa-1 and adenylate cyclase acy-1.
   
  
 0.741
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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