node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F52C6.2 | rbx-1 | F52C6.2.1 | ZK287.5.2 | Ubiquitin-like domain-containing protein. | RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation. | 0.560 |
F52C6.2 | uba-1 | F52C6.2.1 | C47E12.5a.2 | Ubiquitin-like domain-containing protein. | UBA_e1_C domain-containing protein; Belongs to the ubiquitin-activating E1 family. | 0.987 |
F52C6.2 | ubc-14 | F52C6.2.1 | Y87G2A.9.1 | Ubiquitin-like domain-containing protein. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.480 |
F52C6.2 | ubc-7 | F52C6.2.1 | F58A4.10.1 | Ubiquitin-like domain-containing protein. | Probable ubiquitin-conjugating enzyme E2 7; Catalyzes the covalent attachment of ubiquitin to other proteins. | 0.789 |
F52C6.2 | ubq-2 | F52C6.2.1 | ZK1010.1.1 | Ubiquitin-like domain-containing protein. | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] | 0.885 |
F52C6.2 | uev-1 | F52C6.2.1 | F39B2.2.1 | Ubiquitin-like domain-containing protein. | Ubiquitin-conjugating enzyme E2 variant 1; Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own. The uev-1-ubc-13 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies. Required for glr-1-containing glutamate receptor trafficking in neurons. May have a role in synaptic transmission at motorneurons. May be involved in the ubiquitination and growth of intracellular polygluta [...] | 0.856 |
F52C6.2 | uev-3 | F52C6.2.1 | F26H9.7.1 | Ubiquitin-like domain-containing protein. | Ubiquitin-conjugating enzyme E2 variant 3; Possible negative regulator of polyubiquitination (By similarity). May modulate the activity of the p38 MAP kinase pnk-3. May have a role in axon termination and synaptic transmission at motor and mechanosensory neurons. Plays a role in intraflagellar transport in cilia and cilium length regulation ; Belongs to the ubiquitin-conjugating enzyme family. | 0.405 |
F52C6.3 | rbx-1 | F52C6.3.1 | ZK287.5.2 | Ubiquitin-like domain-containing protein. | RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation. | 0.765 |
F52C6.3 | rbx-2 | F52C6.3.1 | R10A10.2.1 | Ubiquitin-like domain-containing protein. | RING-type domain-containing protein. | 0.660 |
F52C6.3 | uba-1 | F52C6.3.1 | C47E12.5a.2 | Ubiquitin-like domain-containing protein. | UBA_e1_C domain-containing protein; Belongs to the ubiquitin-activating E1 family. | 0.934 |
F52C6.3 | ubc-14 | F52C6.3.1 | Y87G2A.9.1 | Ubiquitin-like domain-containing protein. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.729 |
F52C6.3 | ubc-7 | F52C6.3.1 | F58A4.10.1 | Ubiquitin-like domain-containing protein. | Probable ubiquitin-conjugating enzyme E2 7; Catalyzes the covalent attachment of ubiquitin to other proteins. | 0.885 |
F52C6.3 | ubq-1 | F52C6.3.1 | F25B5.4a.2 | Ubiquitin-like domain-containing protein. | Ubiquitin-related; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degrad [...] | 0.486 |
F52C6.3 | ubq-2 | F52C6.3.1 | ZK1010.1.1 | Ubiquitin-like domain-containing protein. | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] | 0.920 |
F52C6.3 | uev-1 | F52C6.3.1 | F39B2.2.1 | Ubiquitin-like domain-containing protein. | Ubiquitin-conjugating enzyme E2 variant 1; Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own. The uev-1-ubc-13 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies. Required for glr-1-containing glutamate receptor trafficking in neurons. May have a role in synaptic transmission at motorneurons. May be involved in the ubiquitination and growth of intracellular polygluta [...] | 0.918 |
F52C6.3 | uev-3 | F52C6.3.1 | F26H9.7.1 | Ubiquitin-like domain-containing protein. | Ubiquitin-conjugating enzyme E2 variant 3; Possible negative regulator of polyubiquitination (By similarity). May modulate the activity of the p38 MAP kinase pnk-3. May have a role in axon termination and synaptic transmission at motor and mechanosensory neurons. Plays a role in intraflagellar transport in cilia and cilium length regulation ; Belongs to the ubiquitin-conjugating enzyme family. | 0.690 |
rbx-1 | F52C6.2 | ZK287.5.2 | F52C6.2.1 | RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation. | Ubiquitin-like domain-containing protein. | 0.560 |
rbx-1 | F52C6.3 | ZK287.5.2 | F52C6.3.1 | RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation. | Ubiquitin-like domain-containing protein. | 0.765 |
rbx-1 | rbx-2 | ZK287.5.2 | R10A10.2.1 | RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation. | RING-type domain-containing protein. | 0.696 |
rbx-1 | uba-1 | ZK287.5.2 | C47E12.5a.2 | RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation. | UBA_e1_C domain-containing protein; Belongs to the ubiquitin-activating E1 family. | 0.838 |