Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| E02D9.1 | M117.3 | E02D9.1a.1 | M117.3.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 14_3_3 domain-containing protein. | 0.752 |
| E02D9.1 | ftt-2 | E02D9.1a.1 | F52D10.3a.3 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 14-3-3-like protein 2; Required for extension of life-span by sir-2.1. Promotes nuclear export of yap-1. Negatively regulates the transcriptional activity of daf-16 by sequestering it to the cytoplasm. Belongs to the 14-3-3 family. | 0.752 |
| E02D9.1 | ksr-2 | E02D9.1a.1 | F58D5.4a.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Kinase suppressor of Ras B; Probable inactive protein kinase which positively regulates Ras-mediated signaling probably acting at the level of let-60/ras or/and lin-45/raf. In the germline, regulates meiotic progression during oogenesis and mpk-1 (isoform b) phosphorylation. Plays a role in meiotic recombination events. Functions redundantly with ksr-1 in the Ras-mediated regulation of larval survival, the development of excretory canal, in determining vulval precursor cell fate during vulval induction and in mpk-1 phosphorylation in somatic cells. | 0.913 |
| E02D9.1 | let-60 | E02D9.1a.1 | ZK792.6.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Ras protein let-60; The level of let-60 controls the switch between vulval and hypodermal cell fates during C.elegans vulval induction. May stimulate the guanine nucleotide exchange factor (GEF) activity of rap-1. Belongs to the small GTPase superfamily. Ras family. | 0.699 |
| E02D9.1 | lin-45 | E02D9.1a.1 | Y73B6A.5b.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Raf homolog serine/threonine-protein kinase; Protein kinase that participates in the induction of vulva and has roles in fertility and viability. Acts downstream of the Ras protein let-60. Required for progression of developing oocytes through the pachytene stage. Plays a role in responses to M.nematophilum- mediated bacterial infection by promoting tail swelling and preventing constipation. Positively regulates lifespan upstream of mek-2 and mpk-1. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. | 0.944 |
| E02D9.1 | mek-2 | E02D9.1a.1 | Y54E10BL.6.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Dual specificity mitogen-activated protein kinase kinase mek-2; Functions in the let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the sur-1/mpk-1 gene product in controlling vulval cell differentiation. Required for progression of developing oocytes through the pachytene stage. Plays a role in responses to M.nematophilum- mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid homeostasis. Positively regulates lifespan upstream of mpk-1. | 0.827 |
| E02D9.1 | mpk-1 | E02D9.1a.1 | F43C1.2b.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase mpk-1; Function in let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the lin-1 gene product in controlling vulval cell differentiation. Plays a negative role in proximal germline proliferation in the mitotic zone. Required for progression of developing oocytes through the pachytene stage. In oocytes, inhibits the activity of the chloride channel clh-3, likely by activating gck-3. Plays a role in response to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid h [...] | 0.862 |
| E02D9.1 | par-5 | E02D9.1a.1 | M117.2a.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 14-3-3-like protein 1. | 0.752 |
| E02D9.1 | rap-1 | E02D9.1a.1 | C27B7.8.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Ras-related protein Rap-1; Required in the hypodermis for proper formation of the cuticle; Belongs to the small GTPase superfamily. Ras family. | 0.683 |
| M117.3 | E02D9.1 | M117.3.1 | E02D9.1a.1 | 14_3_3 domain-containing protein. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.752 |
| M117.3 | ftt-2 | M117.3.1 | F52D10.3a.3 | 14_3_3 domain-containing protein. | 14-3-3-like protein 2; Required for extension of life-span by sir-2.1. Promotes nuclear export of yap-1. Negatively regulates the transcriptional activity of daf-16 by sequestering it to the cytoplasm. Belongs to the 14-3-3 family. | 0.421 |
| M117.3 | ksr-2 | M117.3.1 | F58D5.4a.1 | 14_3_3 domain-containing protein. | Kinase suppressor of Ras B; Probable inactive protein kinase which positively regulates Ras-mediated signaling probably acting at the level of let-60/ras or/and lin-45/raf. In the germline, regulates meiotic progression during oogenesis and mpk-1 (isoform b) phosphorylation. Plays a role in meiotic recombination events. Functions redundantly with ksr-1 in the Ras-mediated regulation of larval survival, the development of excretory canal, in determining vulval precursor cell fate during vulval induction and in mpk-1 phosphorylation in somatic cells. | 0.750 |
| M117.3 | let-60 | M117.3.1 | ZK792.6.1 | 14_3_3 domain-containing protein. | Ras protein let-60; The level of let-60 controls the switch between vulval and hypodermal cell fates during C.elegans vulval induction. May stimulate the guanine nucleotide exchange factor (GEF) activity of rap-1. Belongs to the small GTPase superfamily. Ras family. | 0.627 |
| M117.3 | lin-45 | M117.3.1 | Y73B6A.5b.1 | 14_3_3 domain-containing protein. | Raf homolog serine/threonine-protein kinase; Protein kinase that participates in the induction of vulva and has roles in fertility and viability. Acts downstream of the Ras protein let-60. Required for progression of developing oocytes through the pachytene stage. Plays a role in responses to M.nematophilum- mediated bacterial infection by promoting tail swelling and preventing constipation. Positively regulates lifespan upstream of mek-2 and mpk-1. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. | 0.896 |
| M117.3 | mek-2 | M117.3.1 | Y54E10BL.6.1 | 14_3_3 domain-containing protein. | Dual specificity mitogen-activated protein kinase kinase mek-2; Functions in the let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the sur-1/mpk-1 gene product in controlling vulval cell differentiation. Required for progression of developing oocytes through the pachytene stage. Plays a role in responses to M.nematophilum- mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid homeostasis. Positively regulates lifespan upstream of mpk-1. | 0.752 |
| M117.3 | mpk-1 | M117.3.1 | F43C1.2b.1 | 14_3_3 domain-containing protein. | Mitogen-activated protein kinase mpk-1; Function in let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the lin-1 gene product in controlling vulval cell differentiation. Plays a negative role in proximal germline proliferation in the mitotic zone. Required for progression of developing oocytes through the pachytene stage. In oocytes, inhibits the activity of the chloride channel clh-3, likely by activating gck-3. Plays a role in response to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid h [...] | 0.600 |
| M117.3 | par-5 | M117.3.1 | M117.2a.1 | 14_3_3 domain-containing protein. | 14-3-3-like protein 1. | 0.421 |
| M117.3 | rap-1 | M117.3.1 | C27B7.8.1 | 14_3_3 domain-containing protein. | Ras-related protein Rap-1; Required in the hypodermis for proper formation of the cuticle; Belongs to the small GTPase superfamily. Ras family. | 0.626 |
| ftt-2 | E02D9.1 | F52D10.3a.3 | E02D9.1a.1 | 14-3-3-like protein 2; Required for extension of life-span by sir-2.1. Promotes nuclear export of yap-1. Negatively regulates the transcriptional activity of daf-16 by sequestering it to the cytoplasm. Belongs to the 14-3-3 family. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.752 |
| ftt-2 | M117.3 | F52D10.3a.3 | M117.3.1 | 14-3-3-like protein 2; Required for extension of life-span by sir-2.1. Promotes nuclear export of yap-1. Negatively regulates the transcriptional activity of daf-16 by sequestering it to the cytoplasm. Belongs to the 14-3-3 family. | 14_3_3 domain-containing protein. | 0.421 |
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