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sta-2 protein (Caenorhabditis elegans) - STRING interaction network
"sta-2" - Signal transducer and activator of transcription b in Caenorhabditis elegans
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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sta-2Signal transducer and activator of transcription b; Carries out a dual function- signal transduction and activation of transcription (By similarity). By regulating the up- regulation in the epidermis of antimicrobial peptides nlp-29, plays a role in resistance to fungal infection and in the response to physical wounding and phorbol ester PMA treatment (567 aa)    
Predicted Functional Partners:
mup-4
Transmembrane matrix receptor MUP-4; Required for junctional attachments between hypodermis and muscle, and between the apical epithelial surface and the cuticular matrix. Essential for enclosure of the embryo by the hypodermis, hypodermal integrity, embryo elongation, and maintenance of hypodermal morphology in fully elongated embryos (2104 aa)
     
 
  0.928
snf-12
Transporter; Protein SNF-12 (snf-12) mRNA, complete cds (1022 aa)
     
   
  0.839
nipi-3
Protein nipi-3; By regulating the up-regulation in the epidermis of antimicrobial peptides nlp-29 and nlp-31, plays a role in resistance to fungal infection (655 aa)
           
  0.753
nipi-4
Protein nipi-4; Pseudokinase which plays a role in resistance to fungal infection by promoting expression of antimicrobial peptides (nlp- 29, nlp-31, nlp-34, cnc-1, cnc-2 and cnc-4) in the epidermis. In addition, up-regulates nlp-29 expression upon physical wounding and in response to phorbol ester PMA treatment; Belongs to the protein kinase superfamily. Tyr protein kinase family (396 aa)
     
   
  0.703
nlp-29
Neuropeptide-like protein 29; Antimicrobial peptides that have antibacterial activity against the Gram-negative bacteria S.marcescens. Has antifungal activity against D.coniospora. May play a role in response to physical injury and osmotic stress; Belongs to the YARP (YGGW-amide related peptide) family (73 aa)
     
   
  0.659
dcar-1
L-3,4-dihydroxyphenylalanine receptor; Protein DCAR-1 (dcar-1) mRNA, complete cds (396 aa)
     
   
  0.645
K04G11.3
Protein K04G11.3 (K04G11.3) mRNA, complete cds (368 aa)
           
  0.635
ubc-14
UBiquitin Conjugating enzyme; Protein UBC-14 (ubc-14) mRNA, complete cds; Belongs to the ubiquitin-conjugating enzyme family (170 aa)
       
 
  0.612
ubc-23
UBiquitin Conjugating enzyme; Protein UBC-23 (ubc-23) mRNA, complete cds (395 aa)
     
 
  0.605
tpa-1
Protein kinase C-like 1; Diacylglycerol (DAG)-dependent serine/threonine-protein kinase that phosphorylates a range of cellular proteins (Probable). Phosphorylates mlk-1, a component of the JNK pathway. Involved in axon regeneration after injury probably by activating the JNK pathway. Plays a role in resistance to fungal infection and in wound healing by promoting expression of antimicrobial peptide nlp-29 in the epidermis downstream of gpa-12 and plc-3 and upstream of tir-1-p38-like pathway. Probably by regulating neuronal transmission in ALA neurons, regulates the decrease in pharyng [...] (704 aa)
     
   
  0.598
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Caenorhabditis elegans, Rhabditis elegans, roundworm
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